| Literature DB >> 1805789 |
M Ohuchida1, Y Sasaguri, M Morimatsu, H Nagase, K Yagi.
Abstract
The effect of linoleic acid hydroperoxide on in vitro production of matrix metalloproteinases (MMPs) by human skin fibroblasts was studied. The addition of linoleic acid hydroperoxide significantly increased the production of MMP-1 (tissue collagenase) and MMP-3 (stromelysin), while it rather decreased that of MMP-2 (gelatinase of 72 kDa; so-called "type IV collagenase"). The effect of lipid peroxides to alter collagen metabolism was discussed from pathogenic points of view.Entities:
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Year: 1991 PMID： 1805789
Source DB: PubMed Journal: Biochem Int ISSN： 0158-5231