Literature DB >> 18057743

Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives.

Venkatapuram Padmavathi1, Dandu Rangayapalle Chinna Venkata Subbaiah, Konda Mahesh, Thunga Radha Lakshmi.   

Abstract

Novel amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives were prepared from ethyl 4-phenylsulfonyl-2-(2'-phenylsulfonylethyl)-2-cyanobutyrate (1), ethyl 4-arylsulfonyl-3-aryl-2-cyanobutyrate (7) and ethyl 4-arylmethylsulfonyl-3-aryl-2-cyanobutyrate (8). The lead molecules have been tested for their antimicrobial activity and antioxidant property.

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Year:  2007        PMID： 18057743     DOI： 10.1248/cpb.55.1704

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

Review 1.  Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.

Authors:  Zefeng Zhao; Xufen Dai; Chenyang Li; Xiao Wang; Jiale Tian; Ying Feng; Jing Xie; Cong Ma; Zhuang Nie; Peinan Fan; Mingcheng Qian; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Eur J Med Chem       Date:  2019-11-16       Impact factor: 6.514

2.  Lipophilicity Determination of Antifungal Isoxazolo[3,4-b]pyridin-3(1H)-ones and Their N1-Substituted Derivatives with Chromatographic and Computational Methods.

Authors:  Krzesimir Ciura; Joanna Fedorowicz; Filip Andrić; Petar Žuvela; Katarzyna Ewa Greber; Paweł Baranowski; Piotr Kawczak; Joanna Nowakowska; Tomasz Bączek; Jarosław Sączewski
Journal:  Molecules       Date:  2019-11-26       Impact factor: 4.411

3.  Affinity of Antifungal Isoxazolo[3,4-b]pyridine-3(1H)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography.

Authors:  Krzesimir Ciura; Joanna Fedorowicz; Petar Žuvela; Mario Lovrić; Hanna Kapica; Paweł Baranowski; Wiesław Sawicki; Ming Wah Wong; Jarosław Sączewski
Journal:  Molecules       Date:  2020-10-20       Impact factor: 4.411
  3 in total

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