| Literature DB >> 18057702 |
Toshiya Mori1, Tomoki Yamashita, Kazuo Furihata, Koji Nagai, Ken-Ichi Suzuki, Yoichi Hayakawa, Kazuo Shin-Ya.
Abstract
In the course of our screening program for new inhibitors of IGF-I signaling, we isolated a new cytotoxic antibiotic, burkholone, from the culture broth of Burkholderia sp. QN15488. The structure of burkholone was determined to be (E)-3-methyl-2-(2-octenyl)-4-quinolone by a series of NMR analyses. Burkholone induced cell death 32D/GR15 cells with an IC50 value of 160 nM in IGF-I containing medium, while no cell death was observed in IL-3 containing medium even at the concentration of 37 microM.Entities:
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Year: 2007 PMID： 18057702 DOI： 10.1038/ja.2007.92
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649