Literature DB >> 18055993

Antithymocyte globulin and cyclosporine for treatment of 44 children with hepatitis associated aplastic anemia.

Yuko Osugi1, Hiroshi Yagasaki, Masahiro Sako, Yoshiyuki Kosaka, Takashi Taga, Tsuyoshi Ito, Masuji Yamamoto, Akira Ohara, Takeyuki Sato, Junichi Mimaya, Ichiro Tsukimoto, Seiji Kojima.   

Abstract

We analyzed the outcomes of 44 children with hepatitis associated aplastic anemia (HAA) who received immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA). Fourteen (31.8%) patients achieved complete response and 17 (38.6%) achieved partial response, for an overall response rate of 70.4% after 6 months. Seven non-responders received bone marrow transplantation from an HLA-matched unrelated donor and 6 out of 7 are alive. The probability of overall survival at 10 years was 88.3+/-4.9%, which supports the role of IST with ATG and CsA as treatment of choice for children with HAA without an HLA identical sibling donor.

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Year:  2007        PMID： 18055993     DOI： 10.3324/haematol.11359

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  16 in total

1.  Acute liver failure and aplastic anemia in an 11-year-old girl.

Authors:  Ann Ming Yeh; Amirkaveh Mojtahed; Dorsey Bass
Journal:  Dig Dis Sci       Date:  2011-03-26       Impact factor: 3.199

2.  Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus.

Authors:  Masataka Ishimura; Shouichi Ohga; Masako Ichiyama; Koichi Kusuhara; Hidetoshi Takada; Toshiro Hara; Masaharu Takahashi; Hiroaki Okamoto
Journal:  Eur J Pediatr       Date:  2009-12-09       Impact factor: 3.183

3.  Etiology and survival of aplastic anemia: a study based on clinical investigation.

Authors:  Dharmendra Jain; Ritesh Kumar; Neetu Tyagi; Avinash Negi; Amit Pande; Amita Mahajan; Prashant K Pandey; Radhika Malik; Vimarsh Raina; Balwant K Malik
Journal:  J Clin Lab Anal       Date:  2012-11       Impact factor: 2.352

Review 4.  Hepatitis associated aplastic anemia: a review.

Authors:  Bisma Rauff; Muhammad Idrees; Shahida Amjad Riaz Shah; Sadia Butt; Azeem M Butt; Liaqat Ali; Abrar Hussain; Muhammad Ali
Journal:  Virol J       Date:  2011-02-28       Impact factor: 4.099

Review 5.  The optimal immunosuppressive therapy for aplastic anemia.

Authors:  Seung Hwan Shin; Jong Wook Lee
Journal:  Int J Hematol       Date:  2013-04-19       Impact factor: 2.490

6.  Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.

Authors:  Sung-Yong Kim; Jennifer Le Rademacher; Joseph H Antin; Paolo Anderlini; Mouhab Ayas; Minoo Battiwalla; Jeanette Carreras; Joanne Kurtzberg; Ryotaro Nakamura; Mary Eapen; H Joachim Deeg
Journal:  Haematologica       Date:  2014-08-08       Impact factor: 9.941

7.  Time and residual hematopoiesis are crucial for PNH clones escape in hepatitis-associated aplastic anemia.

Authors:  Wenrui Yang; Xin Zhao; Guangxin Peng; Li Zhang; Liping Jing; Kang Zhou; Yang Li; Lei Ye; Yuan Li; Jianping Li; Huihui Fan; Yang Yang; Fengkui Zhang
Journal:  Ann Hematol       Date:  2021-07-16       Impact factor: 3.673

8.  Aplastica anemia and viral hepatitis.

Authors:  Laura Cudillo
Journal:  Mediterr J Hematol Infect Dis       Date:  2009-12-26       Impact factor: 2.576

9.  Outcomes of Severe Seronegative Hepatitis-associated Aplastic Anemia: A Pediatric Case Series.

Authors:  Sarah Kemme; Marisa Stahl; Dania Brigham; Mark A Lovell; Taizo Nakano; Amy G Feldman; Cara Mack
Journal:  J Pediatr Gastroenterol Nutr       Date:  2021-02-01       Impact factor: 3.288

Review 10.  Parvovirus b19 associated hepatitis.

Authors:  Chhagan Bihari; Archana Rastogi; Priyanka Saxena; Devraj Rangegowda; Ashok Chowdhury; Nalini Gupta; Shiv Kumar Sarin
Journal:  Hepat Res Treat       Date:  2013-10-22
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