PURPOSE: To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. METHODS: Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) were performed. RESULTS: There was a significant reduction (P = 0.011) only in temporal RNFL thickness in patients with MS. P(100) latency was significantly delayed with both 60-min arc checks (P < 0.001) and 15-min arc checks (P < 0.001); however, P(100) amplitude was significantly reduced only in 60-min arc checks (P = 0.026). Rod response b-wave implicit time and standard combined response a- and b-wave implicit times were significantly delayed in patients with MS. Patients with MS with a delayed P(100) latency (21/39; 53.8%) had significantly reduced cone response b-wave amplitude and significantly delayed cone response a- and b-wave implicit times in ERG. mfERG results did not differ between MS and control subjects and between patients with a delayed and a normal P(100) latency. Pearson correlations between RNFL thickness and P(100) amplitude and latency in patients with MS were not significant (P > 0.05). CONCLUSIONS: There is no correlation between RNFL thickness and P(100) response in patients with MS. PVEP seems to be a more reliable biomarker in determining visual pathway involvement in patients with no history of optic neuritis.
PURPOSE: To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. METHODS: Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) were performed. RESULTS: There was a significant reduction (P = 0.011) only in temporal RNFL thickness in patients with MS. P(100) latency was significantly delayed with both 60-min arc checks (P < 0.001) and 15-min arc checks (P < 0.001); however, P(100) amplitude was significantly reduced only in 60-min arc checks (P = 0.026). Rod response b-wave implicit time and standard combined response a- and b-wave implicit times were significantly delayed in patients with MS. Patients with MS with a delayed P(100) latency (21/39; 53.8%) had significantly reduced cone response b-wave amplitude and significantly delayed cone response a- and b-wave implicit times in ERG. mfERG results did not differ between MS and control subjects and between patients with a delayed and a normal P(100) latency. Pearson correlations between RNFL thickness and P(100) amplitude and latency in patients with MS were not significant (P > 0.05). CONCLUSIONS: There is no correlation between RNFL thickness and P(100) response in patients with MS. PVEP seems to be a more reliable biomarker in determining visual pathway involvement in patients with no history of optic neuritis.
Authors: Shiv Saidha; Elias S Sotirchos; Jiwon Oh; Stephanie B Syc; Michaela A Seigo; Navid Shiee; Chistopher Eckstein; Mary K Durbin; Jonathan D Oakley; Scott A Meyer; Teresa C Frohman; Scott Newsome; John N Ratchford; Laura J Balcer; Dzung L Pham; Ciprian M Crainiceanu; Elliot M Frohman; Daniel S Reich; Peter A Calabresi Journal: JAMA Neurol Date: 2013-01 Impact factor: 18.302
Authors: Shiv Saidha; Elias S Sotirchos; Mohamed A Ibrahim; Ciprian M Crainiceanu; Jeffrey M Gelfand; Yasir J Sepah; John N Ratchford; Jiwon Oh; Michaela A Seigo; Scott D Newsome; Laura J Balcer; Elliot M Frohman; Ari J Green; Quan D Nguyen; Peter A Calabresi Journal: Lancet Neurol Date: 2012-10-04 Impact factor: 44.182
Authors: Alexander Klistorner; Prima Sriram; Nikitha Vootakuru; Chenyu Wang; Michael H Barnett; Raymond Garrick; John Parratt; Netta Levin; Noa Raz; Anneke Van der Walt; Lynette Masters; Stuart L Graham; Con Yiannikas Journal: Neurology Date: 2014-05-16 Impact factor: 9.910
Authors: Marta Para-Prieto; Raul Martin; Sara Crespo; Laura Mena-Garcia; Andres Valisena; Lisandro Cordero; Gloria Gonzalez Fernandez; Juan F Arenillas; Nieves Tellez; Jose Carlos Pastor Journal: Clin Ophthalmol Date: 2021-05-14