Literature DB >> 18055073

Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations.

Adam O Whelan1, D Craig Wright, Mark A Chambers, Mahavir Singh, R Glyn Hewinson, H Martin Vordermeier.   

Abstract

Development of cattle vaccines against bovine tuberculosis is a GB research priority. Recently, it has been shown that formalin-killed Bacille Calmette-Guérin (BCG) delivered with the liposomal adjuvant NAX687 imparted significant protection against Mycobacterium bovis infection in the guinea pig aerosol infection model. Extending these studies, we inoculated calves with live BCG, formalin-killed BCG and formalin-killed BCG formulated in NAX687. Live and killed BCG vaccine formulations induced primary effector T-cell populations comparably, both killed BCG formulations also induced potent humoral immune responses. In contrast, live BCG generated enhanced central memory responses against the protective antigen Ag85A whilst killed BCG-induced such responses only poorly. However, the poor capacity of killed BCG to generate central memory could be partially overcome by formulation with NAX687. Measurement of central memory responses induced by TB vaccine candidates in cattle may provide a useful correlate of protection and warrants further investigation in challenge experiments.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18055073     DOI： 10.1016/j.vaccine.2007.11.005

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  16 in total

1.  Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish.

Authors:  J C Hope; M L Thom; M McAulay; E Mead; H M Vordermeier; D Clifford; R G Hewinson; B Villarreal-Ramos
Journal:  Clin Vaccine Immunol       Date:  2011-01-12

2.  Duration of immunity against Mycobacterium bovis following neonatal vaccination with bacillus Calmette-Guérin Danish: significant protection against infection at 12, but not 24, months.

Authors:  M L Thom; M McAulay; H M Vordermeier; D Clifford; R G Hewinson; B Villarreal-Ramos; J C Hope
Journal:  Clin Vaccine Immunol       Date:  2012-06-20

3.  Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.

Authors:  W Ray Waters; Mitchell V Palmer; Brian J Nonnecke; Tyler C Thacker; Charles F Capinos Scherer; D Mark Estes; R Glyn Hewinson; H Martin Vordermeier; S Whitney Barnes; Glenn C Federe; John R Walker; Richard J Glynne; Tsungda Hsu; Brian Weinrick; Karolin Biermann; Michelle H Larsen; William R Jacobs
Journal:  Vaccine       Date:  2009-01-09       Impact factor: 3.641

4.  Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model.

Authors:  H Martin Vordermeier; Gillian S Dean; Ida Rosenkrands; Else M Agger; Peter Andersen; Daryan A Kaveh; R Glyn Hewinson; Philip J Hogarth
Journal:  Clin Vaccine Immunol       Date:  2009-07-29

5.  Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis.

Authors:  H Martin Vordermeier; Bernardo Villarreal-Ramos; Paul J Cockle; Martin McAulay; Shelley G Rhodes; Tyler Thacker; Sarah C Gilbert; Helen McShane; Adrian V S Hill; Zhou Xing; R Glyn Hewinson
Journal:  Infect Immun       Date:  2009-06-01       Impact factor: 3.441

Review 6.  Tuberculosis immunity: opportunities from studies with cattle.

Authors:  W Ray Waters; Mitchell V Palmer; Tyler C Thacker; William C Davis; Srinand Sreevatsan; Paul Coussens; Kieran G Meade; Jayne C Hope; D Mark Estes
Journal:  Clin Dev Immunol       Date:  2010-12-06

7.  Identifying Bacterial and Host Factors Involved in the Interaction of Mycobacterium bovis with the Bovine Innate Immune Cells.

Authors:  Federico Carlos Blanco; María José Gravisaco; María Mercedes Bigi; Elizabeth Andrea García; Cecilia Marquez; Mike McNeil; Mary Jackson; Fabiana Bigi
Journal:  Front Immunol       Date:  2021-07-15       Impact factor: 7.561

8.  Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.

Authors:  H Martin Vordermeier; R Glyn Hewinson; Robert J Wilkinson; Katalin A Wilkinson; Hannah P Gideon; Douglas B Young; Samantha L Sampson
Journal:  PLoS One       Date:  2012-08-01       Impact factor: 3.240

9.  Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia.

Authors:  Philippe Totte; Aboubakar Yaya; Amadou Sery; Hezron Wesonga; Abel Wade; Jan Naessens; Mamadou Niang; François Thiaucourt
Journal:  PLoS One       Date:  2013-02-28       Impact factor: 3.240

10.  Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis.

Authors:  Elma Z Tchilian; Christiane Desel; Emily K Forbes; Silke Bandermann; Clare R Sander; Adrian V S Hill; Helen McShane; Stefan H E Kaufmann
Journal:  Infect Immun       Date:  2008-12-08       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.