| Literature DB >> 18054686 |
Hannah C Glass1, Shinji Fujimoto, Camilla Ceppi-Cozzio, Agnes I Bartha, Daniel B Vigneron, A James Barkovich, David V Glidden, Donna M Ferriero, Steven P Miller.
Abstract
Periventricular leukomalacia is a risk factor for visual impairment in children born prematurely. The impact of diffuse white-matter injury, as detected on magnetic resonance imaging, on early visual function is unknown. We developed two 5-point visual-gaze scores to analyze the association between this clinical assessment and white-matter injury in 93 premature neonates <34 weeks of gestational age at birth. Older postmenstrual age was associated with higher values of the two gaze scores. Infants with moderate or severe white-matter injury had lower scores than their peers without white-matter injury (0.41 points, 95% confidence interval of 0.13-0.69 for visual fixation score; and 0.70 points, 95% confidence interval of 0.30-1.10 for conjugate score, P < 0.005). Using the results from both scales, a score of >or=9 in an infant examined at >or=36 weeks postmenstrual age predicted normal white matter on magnetic resonance examination, with a sensitivity of 84% and a specificity of 100%. These preliminary findings suggest that white-matter injury affects visual function even before term equivalent postmenstrual age.Entities:
Mesh：
Year: 2008 PMID： 18054686 PMCID： PMC2203614 DOI： 10.1016/j.pediatrneurol.2007.08.019
Source DB: PubMed Journal: Pediatr Neurol ISSN： 0887-8994 Impact factor: 3.372