| Literature DB >> 18054228 |
Robert J Young1, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, Chuen Chan, Marie Charbaut, Chun-wa Chung, Máire A Convery, Henry A Kelly, N Paul King, Savvas Kleanthous, Andrew M Mason, Anthony J Pateman, Angela N Patikis, Ivan L Pinto, Derek R Pollard, Stefan Senger, Gita P Shah, John R Toomey, Nigel S Watson, Helen E Weston.
Abstract
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18054228 DOI： 10.1016/j.bmcl.2007.11.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823