Literature DB >> 18053813

Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations.

Marco Prunotto1, Marc Bacchetta, Swaminathan Jayaraman, Marco Galloni, Guillaume Van Eys, Giulio Gabbiani, Marie-Luce Bochaton-Piallat.   

Abstract

We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.

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Year:  2007        PMID： 18053813     DOI： 10.1016/j.febslet.2007.11.060

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle.

Authors:  Karen J Aitken; Cornelia Tolg; Trupti Panchal; Bruno Leslie; Jeffery Yu; Mohamed Elkelini; Nesrin Sabha; Derrick J Tse; Armando J Lorenzo; Magdy Hassouna; Darius J Bägli
Journal:  Am J Pathol       Date:  2009-12-17       Impact factor: 4.307

2.  Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

Authors:  Christina L Papke; Jiumei Cao; Callie S Kwartler; Carlos Villamizar; Katerina L Byanova; Soon-Mi Lim; Harini Sreenivasappa; Grant Fischer; John Pham; Meredith Rees; Miranda Wang; Christine Chaponnier; Giulio Gabbiani; Aarif Y Khakoo; Joya Chandra; Andreea Trache; Warren Zimmer; Dianna M Milewicz
Journal:  Hum Mol Genet       Date:  2013-04-15       Impact factor: 6.150

3.  Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices-A Systematic Study.

Authors:  Daniela Arbeiter; Thomas Reske; Michael Teske; Dalibor Bajer; Volkmar Senz; Klaus-Peter Schmitz; Niels Grabow; Stefan Oschatz
Journal:  Polymers (Basel)       Date:  2021-01-18       Impact factor: 4.329
  3 in total

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