| Literature DB >> 18053714 |
Robert J Young1, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, Chuen Chan, Marie Charbaut, Máire A Convery, Hawa Diallo, Eric Hortense, Wendy R Irving, Henry A Kelly, N Paul King, Savvas Kleanthous, Andrew M Mason, Anthony J Pateman, Angela N Patikis, Ivan L Pinto, Derek R Pollard, Stefan Senger, Gita P Shah, John R Toomey, Nigel S Watson, Helen E Weston, Ping Zhou.
Abstract
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activities and encouraging oral pharmacokinetic profiles.Entities:
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Year: 2007 PMID： 18053714 DOI： 10.1016/j.bmcl.2007.11.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823