| Literature DB >> 18052191 |
Anup M Jawalekar1, Nico Meeuwenoord, J Sjef G O Cremers, Herman S Overkleeft, Gijs A van der Marel, Floris P J T Rutjes, Floris L van Delft.
Abstract
A procedure is presented for copper(I)-catalyzed [3+2] cycloaddition of nucleosides and nucleotides in near-quantitative yield. Azido-alkyne cycloaddition was applied for the preparation of a range of adenosine dimers and derivatives with versatile functionality, as well as for the smooth condensation of two oligonucleotide strands. The described technology may find valuable application in the synthesis of oligonucleotide dimers and conjugates.Entities:
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Year: 2007 PMID： 18052191 DOI： 10.1021/jo702023s
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354