| Literature DB >> 18052025 |
Takeo Urakami1, Shuji Akai, Yurie Katayama, Norihiro Harada, Hideo Tsukada, Naoto Oku.
Abstract
Positron-emission tomography (PET) is a noninvasive real-time functional imaging system and is expected to be useful for the development of new drug candidates in clinical trials. For its application with preformulated liposomes, we devised an optimized [18F]-compound and developed a direct liposome modification method that we termed the "solid-phase transition method". We were successful in using 1-[18F]fluoro-3,6-dioxatetracosane ([18F]7a) for in vivo trafficking of liposomes. This method might be a useful tool in preclinical and clinical studies of lipidic particle-related drugs.Entities:
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Year: 2007 PMID： 18052025 DOI： 10.1021/jm7010518
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446