| Literature DB >> 1805194 |
R E Royer1, R G Mills, L M Deck, G J Mertz, D L Vander Jagt.
Abstract
Gossypol (I) and its derivatives gossylic nitrile-1,1'-diacetate (II), gossylic iminolactone (III) and gossylic lactone (IV) inhibit the replication of human immunodeficiency virus type 1 in vitro in the order III greater than I greater than II,IV, indicating that derivatives of gossypol can retain antiviral activities. All of the derivatives are less cytotoxic than gossypol.Entities:
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Year: 1991 PMID： 1805194 DOI： 10.1016/1043-6618(91)90045-y
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658