Literature DB >> 18051671

Rapid assessment of exposure to chlorine released from a train derailment and resulting health impact.

Mary Anne Wenck1, David Van Sickle, Daniel Drociuk, Amy Belflower, Claire Youngblood, M David Whisnant, Richard Taylor, Veleta Rudnick, James J Gibson.   

Abstract

OBJECTIVES: After a train derailment released approximately 60 tons of chlorine from a ruptured tanker car, a multiagency team performed a rapid assessment of the health impact to determine morbidity caused by the chlorine and evaluate the effect of this mass-casualty event on health-care facilities.
METHODS: A case was defined as death or illness related to chlorine exposure. Investigators gathered information on exposure, treatment received, and outcome through patient questionnaires and medical record review. An exposure severity rating was assigned to each patient based on description of exposure, distance from derailment, and duration of exposure. A case involving death or hospitalization > or = 3 nights was classified as a severe medical outcome. Logistic regression was used to examine factors associated with severe medical outcomes.
RESULTS: Nine people died, 72 were hospitalized in nine hospitals, and 525 were examined as outpatients. Fifty-one people (8%) had a severe medical outcome. Of 263 emergency department visits within 24 hours of the incident, 146 (56%) were in Augusta, Georgia; at least 95 patients arrived at facilities in privately owned vehicles. Patients with moderate-to-extreme exposure were more likely to experience a severe medical outcome (relative risk: 15.2; 95% confidence interval 4.8, 47.8) than those with a lower rating.
CONCLUSIONS: The rapid investigation revealed significant morbidity and mortality associated with an accidental release of chlorine gas. Key findings that should be addressed during facility, community, state, and regional mass-casualty planning include self-transport of symptomatic people for medical care and impact on health-care facilities over a wide geographic area.

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Year:  2007        PMID: 18051671      PMCID: PMC1997246          DOI: 10.1177/003335490712200610

Source DB:  PubMed          Journal:  Public Health Rep        ISSN: 0033-3549            Impact factor:   2.792


  3 in total

1.  Public health consequences from hazardous substances acutely released during rail transit--South Carolina, 2005; selected States, 1999-2004.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2005-01-28       Impact factor: 17.586

2.  Panel classification of self-reported exposure histories: a useful exposure index after a mass-casualty event.

Authors:  David Van Sickle; Mary Anne Wenck; Anne Wenck; Amy Belflower; Dan Drociuk; Jill Ferdinands
Journal:  Public Health Rep       Date:  2007 Nov-Dec       Impact factor: 2.792

3.  Lung function after acute chlorine exposure.

Authors:  R N Jones; J M Hughes; H Glindmeyer; H Weill
Journal:  Am Rev Respir Dis       Date:  1986-12
  3 in total
  35 in total

1.  Posttraumatic stress and tendency to panic in the aftermath of the chlorine gas disaster in Graniteville, South Carolina.

Authors:  Jay P Ginsberg; Joseph R Holbrook; Debjani Chanda; Haikun Bao; Erik R Svendsen
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2011-11-10       Impact factor: 4.328

2.  Medical Response to a Vinyl Chloride Release From a Train Derailment: New Jersey, 2012.

Authors:  Alice M Shumate; Jamille Taylor; Elizabeth McFarland; Christina Tan; Mary Anne Duncan
Journal:  Disaster Med Public Health Prep       Date:  2017-03-06       Impact factor: 1.385

3.  The CounterACT Research Network: basic mechanisms and practical applications.

Authors:  David A Jett; David T Yeung
Journal:  Proc Am Thorac Soc       Date:  2010-07

4.  Follow-up assessment of health consequences after a chlorine release from a train derailment--Graniteville, SC, 2005.

Authors:  Mary Anne Duncan; Daniel Drociuk; Amy Belflower-Thomas; David Van Sickle; James J Gibson; Claire Youngblood; W Randolph Daley
Journal:  J Med Toxicol       Date:  2011-03

5.  Panel classification of self-reported exposure histories: a useful exposure index after a mass-casualty event.

Authors:  David Van Sickle; Mary Anne Wenck; Anne Wenck; Amy Belflower; Dan Drociuk; Jill Ferdinands
Journal:  Public Health Rep       Date:  2007 Nov-Dec       Impact factor: 2.792

Review 6.  A review of the literature on the validity of mass casualty triage systems with a focus on chemical exposures.

Authors:  Joan M Culley; Erik Svendsen
Journal:  Am J Disaster Med       Date:  2014

7.  Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature.

Authors:  Jaideep Honavar; Eddie Bradley; Kelley Bradley; Joo Yeun Oh; Matthew O Vallejo; Eric E Kelley; Nadiezhda Cantu-Medellin; Stephen Doran; Louis J Dell'italia; Sadis Matalon; Rakesh P Patel
Journal:  Toxicology       Date:  2014-04-24       Impact factor: 4.221

8.  Chlorine gas: an evolving hazardous material threat and unconventional weapon.

Authors:  Robert Jones; Brandon Wills; Christopher Kang
Journal:  West J Emerg Med       Date:  2010-05

9.  Simultaneous Measurement of 3-Chlorotyrosine and 3,5-Dichlorotyrosine in Whole Blood, Serum and Plasma by Isotope Dilution HPLC-MS-MS.

Authors:  Brian S Crow; Jennifer Quiñones-González; Brooke G Pantazides; Jonas W Perez; W Rucks Winkeljohn; Joshua W Garton; Jerry D Thomas; Thomas A Blake; Rudolph C Johnson
Journal:  J Anal Toxicol       Date:  2016-03-13       Impact factor: 3.367

10.  Acute health effects after exposure to chlorine gas released after a train derailment.

Authors:  David Van Sickle; Mary Anne Wenck; Amy Belflower; Dan Drociuk; Jill Ferdinands; Fernando Holguin; Erik Svendsen; Lena Bretous; Shirley Jankelevich; James J Gibson; Paul Garbe; Ronald L Moolenaar
Journal:  Am J Emerg Med       Date:  2009-01       Impact factor: 2.469

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