BACKGROUND: Pancreatic cancer is a major contributor to cancer mortality. Studies suggest that a few risk factors, including cigarette smoking, body mass index, having a relative with pancreatic cancer, and diabetes may be related to pancreatic cancer risk. AIM OF THE STUDY: We conducted a case-control study in southeastern Michigan to examine the relation between the above mentioned risk factors and mutations of the K-ras oncogene and p53 tumor suppressor gene. METHODS: Two hundred forty-five patients with newly diagnosed pancreatic cancer and 420 general population controls were enrolled in the study. For this analysis, all case subjects were restricted to the pancreatic cancer patients that had tissue blocks available for study (n = 51). In-person interviews were conducted to ascertain information on demographic and lifestyle factors. Adjusted logistic regression analyses were conducted to compare various subject characteristics of pancreatic cancer patients with K-ras and p53 mutations and their subtypes to the characteristics of the general population controls. RESULTS: Smoking (adjusted odds ratio [aOR] = 2.0; 95% confidence interval [95%CI] = 0.9-4.3) and diabetes diagnosed 5 or more years before interview (aOR = 3.4; 95%CI = 1.3-8.8) were associated with pancreatic cancer patients positive for K-ras codon 12 mutations, but not with pancreatic cancer patients negative for K-ras codon 12 mutations. On the other hand, none of the examined risk factors were meaningfully related to patients with p53 mutations. CONCLUSIONS: This study suggests that some recognized risk factors for pancreatic cancer may also be associated with K-ras codon 12 mutations. However, further large-scale studies are warranted.
BACKGROUND:Pancreatic cancer is a major contributor to cancer mortality. Studies suggest that a few risk factors, including cigarette smoking, body mass index, having a relative with pancreatic cancer, and diabetes may be related to pancreatic cancer risk. AIM OF THE STUDY: We conducted a case-control study in southeastern Michigan to examine the relation between the above mentioned risk factors and mutations of the K-ras oncogene and p53tumor suppressor gene. METHODS: Two hundred forty-five patients with newly diagnosed pancreatic cancer and 420 general population controls were enrolled in the study. For this analysis, all case subjects were restricted to the pancreatic cancerpatients that had tissue blocks available for study (n = 51). In-person interviews were conducted to ascertain information on demographic and lifestyle factors. Adjusted logistic regression analyses were conducted to compare various subject characteristics of pancreatic cancerpatients with K-ras and p53 mutations and their subtypes to the characteristics of the general population controls. RESULTS: Smoking (adjusted odds ratio [aOR] = 2.0; 95% confidence interval [95%CI] = 0.9-4.3) and diabetes diagnosed 5 or more years before interview (aOR = 3.4; 95%CI = 1.3-8.8) were associated with pancreatic cancerpatients positive for K-ras codon 12 mutations, but not with pancreatic cancerpatients negative for K-ras codon 12 mutations. On the other hand, none of the examined risk factors were meaningfully related to patients with p53 mutations. CONCLUSIONS: This study suggests that some recognized risk factors for pancreatic cancer may also be associated with K-ras codon 12 mutations. However, further large-scale studies are warranted.
Authors: M Schenk; A G Schwartz; E O'Neal; M Kinnard; J K Greenson; J P Fryzek; G S Ying; D H Garabrant Journal: J Natl Cancer Inst Date: 2001-04-18 Impact factor: 13.506
Authors: Jon P Fryzek; Maryjean Schenk; Margaret Kinnard; Joel K Greenson; David H Garabrant Journal: Am J Epidemiol Date: 2005-06-29 Impact factor: 4.897
Authors: R H Hruban; A D van Mansfeld; G J Offerhaus; D H van Weering; D C Allison; S N Goodman; T W Kensler; K K Bose; J L Cameron; J L Bos Journal: Am J Pathol Date: 1993-08 Impact factor: 4.307
Authors: F H Sarkar; M Valdivieso; J Borders; K L Yao; M M Raval; S K Madan; P Sreepathi; R Shimoyama; Z Steiger; D W Visscher Journal: Diagn Mol Pathol Date: 1995-12
Authors: Tomàs López; José A Pumarega; Anna Z Pollack; Duk-Hee Lee; Lorenzo Richiardi; David R Jacobs; Enrique F Schisterman; Miquel Porta Journal: Chemosphere Date: 2014-05-20 Impact factor: 7.086
Authors: Amanda Blackford; Giovanni Parmigiani; Thomas W Kensler; Christopher Wolfgang; Siân Jones; Xiaosong Zhang; D Willams Parsons; Jimmy Cheng-Ho Lin; Rebecca J Leary; James R Eshleman; Michael Goggins; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Alison Klein; John L Cameron; Kelly Olino; Richard Schulick; Jordan Winter; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler; Ralph H Hruban Journal: Cancer Res Date: 2009-04-07 Impact factor: 12.701
Authors: Irina Mordukhovich; Pavel Rossner; Mary Beth Terry; Regina Santella; Yu-Jing Zhang; Hanina Hibshoosh; Lorenzo Memeo; Mahesh Mansukhani; Chang-Min Long; Gail Garbowski; Meenakshi Agrawal; Mia M Gaudet; Susan E Steck; Sharon K Sagiv; Sybil M Eng; Susan L Teitelbaum; Alfred I Neugut; Kathleen Conway-Dorsey; Marilie D Gammon Journal: Environ Health Perspect Date: 2009-11-18 Impact factor: 9.031
Authors: Winnie S Liang; David W Craig; John Carpten; Mitesh J Borad; Michael J Demeure; Glen J Weiss; Tyler Izatt; Shripad Sinari; Alexis Christoforides; Jessica Aldrich; Ahmet Kurdoglu; Michael Barrett; Lori Phillips; Hollie Benson; Waibhav Tembe; Esteban Braggio; Jeffrey A Kiefer; Christophe Legendre; Richard Posner; Galen H Hostetter; Angela Baker; Jan B Egan; Haiyong Han; Douglas Lake; Edward C Stites; Ramesh K Ramanathan; Rafael Fonseca; A Keith Stewart; Daniel Von Hoff Journal: PLoS One Date: 2012-10-10 Impact factor: 3.240