Literature DB >> 18048957

Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells.

Radosław Pilarski1, Magdalena Poczekaj-Kostrzewska, Danuta Ciesiołka, Krzysztof Szyfter, Krzysztof Gulewicz.   

Abstract

The woody Amazonian vine Uncaria tomentosa (cat's claw) has been recently more and more popular all over the world as an immunomodulatory, antiinflammatory and anti-cancer remedy. This study investigates anti-proliferative potency of several cat's claw preparations with different quantitative and qualitative alkaloid contents on HL-60 acute promyelocytic human cells by applying trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT). By standardization and statistical comparison of the obtained results pteropodine and isomitraphylline are indicated to be most suitable for standardization of medical cat's claw preparations.

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Year:  2007        PMID： 18048957

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  7 in total

1.  Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity.

Authors:  Anita Kośmider; Edyta Czepielewska; Mieczysław Kuraś; Krzysztof Gulewicz; Wioleta Pietrzak; Renata Nowak; Grażyna Nowicka
Journal:  Molecules       Date:  2017-04-12       Impact factor: 4.411

2.  Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours.

Authors:  Ali Zari; Hajer Alfarteesh; Carly Buckner; Robert Lafrenie
Journal:  Molecules       Date:  2021-02-18       Impact factor: 4.411

3.  Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity.

Authors:  Arturo Alejandro Dreifuss; Amanda Leite Bastos-Pereira; Isabella Aviles Fabossi; Francislaine Aparecida Dos Reis Lívero; Aline Maria Stolf; Carlos Eduardo Alves de Souza; Liana de Oliveira Gomes; Rodrigo Polimeni Constantin; Aline Emmer Ferreira Furman; Regiane Lauriano Batista Strapasson; Simone Teixeira; Aleksander Roberto Zampronio; Marcelo Nicolás Muscará; Maria Elida Alves Stefanello; Alexandra Acco
Journal:  PLoS One       Date:  2013-02-07       Impact factor: 3.240

4.  Poly ɛ-caprolactone nanoparticles loaded with Uncaria tomentosa extract: preparation, characterization, and optimization using the Box-Behnken design.

Authors:  Ana Ferreira Ribeiro; Ricardo Leite de Oliveira Rezende; Lúcio Mendes Cabral; Valéria Pereira de Sousa
Journal:  Int J Nanomedicine       Date:  2013-01-25

5.  Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.

Authors:  Flávia C M Lopes; Ana Rocha; Ana Pirraco; Luis O Regasini; Dulce H S Silva; Vanderlan S Bolzani; Isabel Azevedo; Iracilda Z Carlos; Raquel Soares
Journal:  BMC Complement Altern Med       Date:  2009-05-22       Impact factor: 3.659

6.  High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors.

Authors:  S Deiab; E Mazzio; S Messeha; N Mack; K F A Soliman
Journal:  European J Med Plants       Date:  2013

7.  Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of Geissospermum reticulatum Bark.

Authors:  Joanna J Sajkowska-Kozielewicz; Paweł Kozielewicz; Nicholas M Barnes; Iwona Wawer; Katarzyna Paradowska
Journal:  Oxid Med Cell Longev       Date:  2016-06-29       Impact factor: 6.543
  7 in total

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