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Literature DB >> 18047841

The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance.

Abstract

In 1985, we reported that a naturally occurring human antibody (anti-Gal), produced as the most abundant antibody (1% of immunoglobulins) throughout the life of all individuals, recognizes a carbohydrate epitope Galalpha1-3Galbeta1-4GlcNAc-R (the alpha-gal epitope). Since that time, an extensive literature has developed on discoveries related to the alpha-gal epitope and the anti-Gal antibody, including the barrier they form in xenotransplantation and their reciprocity in mammalian evolution. This review covers these topics and new avenues of clinical importance related to this unique antigen/antibody system (alpha-gal epitope/anti-Gal) in improving the efficacy of viral vaccines and in immunotherapy against cancer.

Entities: Chemical Disease Gene Species

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Year: 2007 PMID： 18047841 PMCID： PMC2271034 DOI： 10.1016/j.bbagen.2007.11.003

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

127 in total

1. A simple method for the isolation and purification of total lipides from animal tissues.

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Journal: J Biol Chem Date: 1957-05 Impact factor: 5.157

Review 2. Function and heterogeneity of human Fc receptors for immunoglobulin G.

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Journal: J Clin Invest Date: 1989-02 Impact factor: 14.808

3. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.

Authors: Kenji Kuwaki; Yau-Lin Tseng; Frank J M F Dor; Akira Shimizu; Stuart L Houser; Todd M Sanderson; Courtney J Lancos; Derek D Prabharasuth; Jane Cheng; Kathleen Moran; Yosuke Hisashi; Nicolas Mueller; Kazuhiko Yamada; Julia L Greenstein; Robert J Hawley; Clive Patience; Michel Awwad; Jay A Fishman; Simon C Robson; Henk-Jan Schuurman; David H Sachs; David K C Cooper
Journal: Nat Med Date: 2004-12-26 Impact factor: 53.440

4. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.

Authors: Kazuhiko Yamada; Koji Yazawa; Akira Shimizu; Takehiro Iwanaga; Yosuke Hisashi; Matthew Nuhn; Patricia O'Malley; Shuji Nobori; Parsia A Vagefi; Clive Patience; Jay Fishman; David K C Cooper; Robert J Hawley; Julia Greenstein; Henk-Jan Schuurman; Michel Awwad; Megan Sykes; David H Sachs
Journal: Nat Med Date: 2004-12-26 Impact factor: 53.440

5. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

Authors: U Galili; S B Shohet; E Kobrin; C L Stults; B A Macher
Journal: J Biol Chem Date: 1988-11-25 Impact factor: 5.157

6. Structure elucidation of blood group B-like and I-active ceramide eicosa- and pentacosasaccharides from rabbit erythrocyte membranes by combined gas chromatography-mass spectrometry; electron-impact and fast-atom-bombardment mass spectrometry; and two-dimensional correlated, relayed-coherence transfer, and nuclear Overhauser effect 500-MHz 1H-n.m.r. spectroscopy.

Authors: P Hanfland; M Kordowicz; J Peter-Katalinić; H Egge; J Dabrowski; U Dabrowski
Journal: Carbohydr Res Date: 1988-07-15 Impact factor: 2.104

7. Use of the enzyme-linked immunoadsorbent assay to monitor the purification of glycosphingolipid antigens by high-performance liquid chromatography.

Authors: J Buehler; U Galili; B A Macher
Journal: Anal Biochem Date: 1987-08-01 Impact factor: 3.365

8. Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells.

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Journal: J Biol Chem Date: 1988-11-25 Impact factor: 5.157

9. Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase.

Authors: Yingnan Zhang; Ashlesha Deshpande; Zhihong Xie; Ramanathan Natesh; K Ravi Acharya; Keith Brew
Journal: Glycobiology Date: 2004-06-30 Impact factor: 4.313

10. Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora.

Authors: U Galili; R E Mandrell; R M Hamadeh; S B Shohet; J M Griffiss
Journal: Infect Immun Date: 1988-07 Impact factor: 3.441

129 in total

1. Single agent panitumumab in KRAS wild-type metastatic colorectal cancer patients following cetuximab-based regimens: Clinical outcome and biomarkers of efficacy.

Authors: Filippo Pietrantonio; Federica Perrone; Pamela Biondani; Claudia Maggi; Andrea Lampis; Claudia Bertan; Filippo Venturini; Luca Tondulli; Daris Ferrari; Vincenzo Ricci; Federica Villa; Gloria Barone; Nadia Bianco; Antonio Ghidini; Ilaria Bossi; Giuseppe Fanetti; Maria Di Bartolomeo; Filippo de Braud
Journal: Cancer Biol Ther Date: 2013-09-04 Impact factor: 4.742

2. Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose.

Authors: Scott P Commins; Hayley R James; Whitney Stevens; Shawna L Pochan; Michael H Land; Carol King; Susan Mozzicato; Thomas A E Platts-Mills
Journal: J Allergy Clin Immunol Date: 2014-03-20 Impact factor: 10.793

3. Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signalling in HepG2 cells and C57BL/6J mice.

Authors: S Bhattacharyya; I O-Sullivan; S Katyal; T Unterman; J K Tobacman
Journal: Diabetologia Date: 2011-10-20 Impact factor: 10.122

4. Host-Specific Glycans Are Correlated with Susceptibility to Infection by Lagoviruses, but Not with Their Virulence.

Authors: Ana M Lopes; Adrien Breiman; Mónica Lora; Béatrice Le Moullac-Vaidye; Oxana Galanina; Kristina Nyström; Stephane Marchandeau; Ghislaine Le Gall-Reculé; Tanja Strive; Aleksija Neimanis; Nicolai V Bovin; Nathalie Ruvoën-Clouet; Pedro J Esteves; Joana Abrantes; Jacques Le Pendu
Journal: J Virol Date: 2018-01-30 Impact factor: 5.103

5. Synthesis of Galα(1,3)Galβ(1,4)GlcNAcα-, Galβ(1,4)GlcNAcα- and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease.

Authors: Nathaniel S Schocker; Susana Portillo; Carlos R N Brito; Alexandre F Marques; Igor C Almeida; Katja Michael
Journal: Glycobiology Date: 2015-09-18 Impact factor: 4.313

6. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose.

Authors: Scott P Commins; Shama M Satinover; Jacob Hosen; Jonathan Mozena; Larry Borish; Barrett D Lewis; Judith A Woodfolk; Thomas A E Platts-Mills
Journal: J Allergy Clin Immunol Date: 2008-12-13 Impact factor: 10.793