| Literature DB >> 18047371 |
Jae Hoon Lee1, Bo Seung Choi, Jay Hyok Chang, Hee Bong Lee, Joo-Yong Yoon, Jaeick Lee, Hyunik Shin.
Abstract
Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided beta-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride.Entities:
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Year: 2007 PMID： 18047371 DOI： 10.1021/jo701743m
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354