| Literature DB >> 18046644 |
Egidia Costanzi1, Sabata Martino, Emanuele Persichetti, Roberto Tiribuzi, Carlo Massini, Giorgio Bernardi, Antonio Orlacchio, Aldo Orlacchio.
Abstract
Several therapies for Alzheimer's Disease (AD) are currently under investigation. Some studies have reported that concentration of vitamins in biological fluids are lower in AD patients compared to control subjects and clinical evidence has shown the therapeutic potential of vitamin C and E in delaying AD progression. However, the molecular mechanism(s) that are engaged upon their administration in the APP metabolism in vitro or in vivo still need clarifying. Here, we investigate the effects of vitamin C supplementation, at physiological concentration, in skin fibroblasts obtained from SAD and FAD patients. This study shows that SAD patients' fibroblasts exhibited the exclusive appearance of C-terminal fragments, derived from APP processing, without giving rise to the beta-amyloid peptide, other than corresponding decreased levels of lysosomal enzymes, such as beta-hexosaminidase, alpha-mannosidase and cathepsins B, L, and D.Entities:
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Year: 2007 PMID： 18046644 DOI： 10.1007/s11064-007-9539-y
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996