OBJECTIVES: We assessed the effectiveness and safety of the sirolimus-eluting stent (SES) in the treatment of chronic total coronary occlusions. BACKGROUND: Chronic total occlusions (CTO) of coronary vessels have an unacceptable high restenosis rate of approximately 50% after stenting. Few data exist about the performance of drug eluting stents (DES) in the treatment of CTO. METHODS: All coronary interventions using the Cypher stent performed at 122 centers engaged in the German Cypher registry between April 2002 and December 2004 were analyzed; a total of 5,344 patients; 374 with and 4,970 without CTO were compared. RESULTS: There was no significant difference between both groups regarding demographics, coronary status and left ventricular function. Patients in the CTO group had a higher level of angina symptoms, the coronary lesions were more complex and the stents used were smaller and longer than in the No-CTO group. The In-hospital outcome was similar in both groups, with importantly no difference regarding mortality and complications. Stenting was as successful in the CTO as in the No-CTO group; during a follow-up of 6.6 months we found no significant difference regarding the rate of mortality, complications, and revascularization between both groups. CONCLUSIONS: Implantation of the Cypher stent reduces the restenosis rate and seems to be a safe and effective tool for the treatment of chronic total coronary occlusions.
OBJECTIVES: We assessed the effectiveness and safety of the sirolimus-eluting stent (SES) in the treatment of chronic total coronary occlusions. BACKGROUND: Chronic total occlusions (CTO) of coronary vessels have an unacceptable high restenosis rate of approximately 50% after stenting. Few data exist about the performance of drug eluting stents (DES) in the treatment of CTO. METHODS: All coronary interventions using the Cypher stent performed at 122 centers engaged in the German Cypher registry between April 2002 and December 2004 were analyzed; a total of 5,344 patients; 374 with and 4,970 without CTO were compared. RESULTS: There was no significant difference between both groups regarding demographics, coronary status and left ventricular function. Patients in the CTO group had a higher level of angina symptoms, the coronary lesions were more complex and the stents used were smaller and longer than in the No-CTO group. The In-hospital outcome was similar in both groups, with importantly no difference regarding mortality and complications. Stenting was as successful in the CTO as in the No-CTO group; during a follow-up of 6.6 months we found no significant difference regarding the rate of mortality, complications, and revascularization between both groups. CONCLUSIONS: Implantation of the Cypher stent reduces the restenosis rate and seems to be a safe and effective tool for the treatment of chronic total coronary occlusions.
Authors: Ahmed A Khattab; Christian W Hamm; Jochen Senges; Ralph Toelg; Volker Geist; Tassilo Bonzel; Malte Kelm; Benny Levenson; Christoph A Nienaber; Georg Sabin; Ulrich Tebbe; Steffen Schneider; Gert Richardt Journal: Clin Res Cardiol Date: 2007-02-26 Impact factor: 5.460
Authors: P W Serruys; V Umans; G R Heyndrickx; M van den Brand; P J de Feyter; W Wijns; B Jaski; P G Hugenholtz Journal: Eur Heart J Date: 1985-01 Impact factor: 29.983
Authors: Gerald S Werner; Andreas Krack; Gero Schwarz; Dirk Prochnau; Stefan Betge; Hans R Figulla Journal: J Am Coll Cardiol Date: 2004-12-21 Impact factor: 24.094
Authors: R Zahn; C W Hamm; U Zeymer; S Schneider; C A Nienaber; G Richardt; M Kelm; B Levenson; T Bonzel; U Tebbe; W A Schöbel; G Sabin; J Senges Journal: Z Kardiol Date: 2004-04
Authors: Timo Baks; Robert-Jan van Geuns; Dirk J Duncker; Filippo Cademartiri; Nico R Mollet; Gabriel P Krestin; Patrick W Serruys; Pim J de Feyter Journal: J Am Coll Cardiol Date: 2006-01-26 Impact factor: 24.094
Authors: D L Fischman; M B Leon; D S Baim; R A Schatz; M P Savage; I Penn; K Detre; L Veltri; D Ricci; M Nobuyoshi Journal: N Engl J Med Date: 1994-08-25 Impact factor: 91.245
Authors: D R Holmes; R E Vlietstra; G S Reeder; J F Bresnahan; H C Smith; A A Bove; H V Schaff Journal: J Am Coll Cardiol Date: 1984-03 Impact factor: 24.094
Authors: Helge Möllmann; Albrecht Elsässer; Holger Nef; Steffen Schneider; Christoph A Nienaber; Gert Richardt; Michael Weber; Malte Kelm; Benny Levenson; Tassilo Bonzel; Ulrich Tebbe; Georg Sabin; Thomas Pfannebecker; Jochen Senges; Christian W Hamm Journal: Clin Res Cardiol Date: 2008-03-03 Impact factor: 5.460
Authors: Bo He; Hong Jiang; Zhibing Lu; Meichun Zhang; Xiaorong Hu; Bo Yang; He Huang; Gang Wu; Jun Wan; Huafen Liu; Xiaohong Wang; Congxin Huang Journal: Clin Res Cardiol Date: 2010-07-21 Impact factor: 5.460