Literature DB >> 18046429

Toward 'SMART' stem cells.

T Cheng1.   

Abstract

Stem cell research is at the heart of regenerative medicine, which holds great promise for the treatment of many devastating disorders. However, in addition to hurdles posed by well-publicized ethical issues, this emerging field presents many biological challenges. What is a stem cell? How are embryonic stem cells different from adult stem cells? What are the physiological bases for therapeutically acceptable stem cells? In this editorial review, I will briefly discuss these superficially simple but actually rather complex issues that surround this fascinating cell type. The goal of this special issue on stem cells in Gene Therapy is to review some fundamental and critical aspects of current stem cell research that have translational potential.

Mesh：

Year:  2007        PMID： 18046429     DOI： 10.1038/sj.gt.3303066

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  15 in total

1.  Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging.

Authors:  Zhenyu Ju; Junling Zhang; Yingdai Gao; Tao Cheng
Journal:  Int J Hematol       Date:  2011-06-14       Impact factor: 2.490

2.  Bid is a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients.

Authors:  Hongmei Shen; Hui Yu; Paulina H Liang; Richard Xufeng; Yifang Song; Xiaoxia Hu; Xiaoyun Chen; Xiao-Ming Yin; Tao Cheng
Journal:  Exp Hematol       Date:  2011-06-16       Impact factor: 3.084

3.  StemCellCKB: An Integrated Stem Cell-Specific Chemogenomics KnowledgeBase for Target Identification and Systems-Pharmacology Research.

Authors:  Yu Zhang; Lirong Wang; Zhiwei Feng; Haizi Cheng; Terence Francis McGuire; Yahui Ding; Tao Cheng; Yingdai Gao; Xiang-Qun Xie
Journal:  J Chem Inf Model       Date:  2016-10-07       Impact factor: 4.956

4.  Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

Authors:  Biquan Luo; Chun-Chih Tseng; Gregor B Adams; Amy S Lee
Journal:  Stem Cells Dev       Date:  2013-08-20       Impact factor: 3.272

5.  Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow.

Authors:  M Lim; Y Pang; S Ma; S Hao; H Shi; Y Zheng; C Hua; X Gu; F Yang; W Yuan; T Cheng
Journal:  Leukemia       Date:  2015-08-04       Impact factor: 11.528

6.  ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.

Authors:  Richard XuFeng; Matthew J Boyer; Hongmei Shen; Yanxin Li; Hui Yu; Yindai Gao; Qiong Yang; Qingde Wang; Tao Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-02       Impact factor: 11.205

7.  The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.

Authors:  Biquan Luo; Ben S Lam; Sung Hyung Lee; Shiuan Wey; Hui Zhou; Miao Wang; Si-Yi Chen; Gregor B Adams; Amy S Lee
Journal:  PLoS One       Date:  2011-05-24       Impact factor: 3.240

8.  Stem cell traits in long-term co-culture revealed by time-lapse imaging.

Authors:  Y Song; A Bahnson; N Hall; H Yu; H Shen; D Koebler; R Houck; Y Xie; T Cheng
Journal:  Leukemia       Date:  2009-10-01       Impact factor: 11.528

9.  An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells.

Authors:  Yanxin Li; Rekha Pal; Li-Ying Sung; Haizhong Feng; Weimin Miao; Shi-Yuan Cheng; Cindy Tian; Tao Cheng
Journal:  PLoS One       Date:  2012-09-26       Impact factor: 3.240

Review 10.  Understanding the "SMART" features of hematopoietic stem cells and beyond.

Authors:  Shiru Yuan; Guohuan Sun; Yawen Zhang; Fang Dong; Hui Cheng; Tao Cheng
Journal:  Sci China Life Sci       Date:  2021-07-30       Impact factor: 6.038
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