Literature DB >> 18045970

Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells.

Stefan Lob1, Alfred Konigsrainer, Richard Schafer, Hans-Georg Rammensee, Gerhard Opelz, Peter Terness.   

Abstract

Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). Here we show that human dendritic cells (DCs) express both IDO-1 and IDO-2, but that only IDO1 mediates tryptophan catabolism; furthermore, its activity is blocked by levo-1MT, whereas D-1MT is inefficient. Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study.

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Year:  2007        PMID： 18045970     DOI： 10.1182/blood-2007-10-116111

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


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