Literature DB >> 18045742

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

Eufrânio N da Silva1, Rubem F S Menna-Barreto, Maria do Carmo F R Pinto, Raphael S F Silva, Daniel V Teixeira, Maria Cecília B V de Souza, Carlos Alberto De Simone, Solange L De Castro, Vitor F Ferreira, Antônio V Pinto.   

Abstract

[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. All the derivatives were more active than the original quinones, with IC(50)/1 day values in the range of 17 to 359 microM, the apolar phenyl substituted triazole 6 being the most active compound. These triazole derivatives of nor-beta-lapachone emerge as interesting new lead compounds in drug development for Chagas disease.

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Year:  2007        PMID： 18045742     DOI： 10.1016/j.ejmech.2007.10.015

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  15 in total

1.  Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications.

Authors:  Renata G Almeida; Wagner O Valença; Luísa G Rosa; Carlos A de Simone; Solange L de Castro; Juliana M C Barbosa; Daniel P Pinheiro; Carlos R K Paier; Guilherme G C de Carvalho; Claudia Pessoa; Marilia O F Goulart; Ammar Kharma; Eufrânio N da Silva Júnior
Journal:  RSC Med Chem       Date:  2020-07-13

2.  In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches.

Authors:  Lina S Prieto Cárdenas; Karen A Arias Soler; Diana L Nossa González; Wilson E Rozo Núñez; Agobardo Cárdenas-Chaparro; Pablo R Duchowicz; Jovanny A Gómez Castaño
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-31

3.  It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.

Authors:  Daisy J B Lima; Renata G Almeida; Guilherme A M Jardim; Breno P A Barbosa; Augusto C C Santos; Wagner O Valença; Marcos R Scheide; Claudia C Gatto; Guilherme G C de Carvalho; Pedro M S Costa; Claudia Pessoa; Cynthia L M Pereira; Claus Jacob; Antonio L Braga; Eufrânio N da Silva Júnior
Journal:  RSC Med Chem       Date:  2021-08-12

4.  Synthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes.

Authors:  Ari Miranda da Silva; Leonardo Araújo-Silva; Ana Cristina S Bombaça; Rubem F S Menna-Barreto; Claudio Eduardo Rodrigues-Santos; Aurélio B Buarque Ferreira; Solange L de Castro
Journal:  Medchemcomm       Date:  2017-02-27       Impact factor: 3.597

5.  Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies.

Authors:  Maria de Nazaré C Soeiro; Solange Lisboa de Castro
Journal:  Open Med Chem J       Date:  2011-03-09

6.  Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

Authors:  Solange L de Castro; Denise G J Batista; Marcos M Batista; Wanderson Batista; Anissa Daliry; Elen M de Souza; Rubem F S Menna-Barreto; Gabriel M Oliveira; Kelly Salomão; Cristiane F Silva; Patricia B Silva; Maria de Nazaré C Soeiro
Journal:  Mol Biol Int       Date:  2011-06-30

7.  Identification of nor-β-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain.

Authors:  André L Lourenço; Paula A Abreu; Bruno Leal; Eufrânio N da Silva Júnior; Antonio V Pinto; Maria do Carmo F R Pinto; Alessandra M T Souza; Juliana S Novais; Marcela B Paiva; Lucio M Cabral; Carlos R Rodrigues; Vitor F Ferreira; Helena C Castro
Journal:  Curr Microbiol       Date:  2010-09-30       Impact factor: 2.343

8.  Antivenom effects of 1,2,3-triazoles against Bothrops jararaca and Lachesis muta snakes.

Authors:  Thaisa F S Domingos; Laura de A Moura; Carla Carvalho; Vinícius R Campos; Alessandro K Jordão; Anna C Cunha; Vitor F Ferreira; Maria Cecília B V de Souza; Eladio F Sanchez; André L Fuly
Journal:  Biomed Res Int       Date:  2013-04-22       Impact factor: 3.411

9.  Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities.

Authors:  Adilson Vidal Costa; Marcos Vinicius Lacerda de Oliveira; Roberta Tristão Pinto; Luiza Carvalheira Moreira; Ediellen Mayara Corrêa Gomes; Thammyres de Assis Alves; Patrícia Fontes Pinheiro; Vagner Tebaldi de Queiroz; Larissa Fonseca Andrade Vieira; Robson Ricardo Teixeira; Waldir Cintra de Jesus Júnior
Journal:  Molecules       Date:  2017-10-07       Impact factor: 4.411

10.  Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.

Authors:  Eduardo H G da Cruz; Molly A Silvers; Guilherme A M Jardim; Jarbas M Resende; Bruno C Cavalcanti; Igor S Bomfim; Claudia Pessoa; Carlos A de Simone; Giancarlo V Botteselle; Antonio L Braga; Divya K Nair; Irishi N N Namboothiri; David A Boothman; Eufrânio N da Silva Júnior
Journal:  Eur J Med Chem       Date:  2016-06-14       Impact factor: 6.514
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