Literature DB >> 18045717

Serotonin2C receptor mRNA editing in neuropathic pain model.

Aya Nakae1, Kunihiro Nakai, Tatsuya Tanaka, Masaki Takashina, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashimo.   

Abstract

We investigated the effects on 5HT(serotonin) 2C receptor RNA editing efficiency of contusive SCI (spinal cord injury). Using cloning followed by sequence analysis on spinal cord samples taken, we compared mRNA editing. Our results might be evidence of a functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18045717     DOI： 10.1016/j.neures.2007.10.004

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  8 in total

1.  5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization.

Authors:  Gregory E Bigford; Nauman S Chaudhry; Robert W Keane; Alice M Holohean
Journal:  J Biol Chem       Date:  2012-01-30       Impact factor: 5.157

2.  Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans.

Authors:  Brian J Mickey; Benjamin J Sanford; Tiffany M Love; Pei-Hong Shen; Colin A Hodgkinson; Christian S Stohler; David Goldman; Jon-Kar Zubieta
Journal:  J Neurosci       Date:  2012-07-04       Impact factor: 6.167

3.  Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.

Authors:  Katherine C Murray; Aya Nakae; Marilee J Stephens; Michelle Rank; Jessica D'Amico; Philip J Harvey; Xiaole Li; R Luke W Harris; Edward W Ballou; Roberta Anelli; Charles J Heckman; Takashi Mashimo; Romana Vavrek; Leo Sanelli; Monica A Gorassini; David J Bennett; Karim Fouad
Journal:  Nat Med       Date:  2010-05-30       Impact factor: 53.440

4.  Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour.

Authors:  Christine M Doe; Dinko Relkovic; Alastair S Garfield; Jeffrey W Dalley; David E H Theobald; Trevor Humby; Lawrence S Wilkinson; Anthony R Isles
Journal:  Hum Mol Genet       Date:  2009-03-20       Impact factor: 6.150

Review 5.  The animal model of spinal cord injury as an experimental pain model.

Authors:  Aya Nakae; Kunihiro Nakai; Kenji Yano; Ko Hosokawa; Masahiko Shibata; Takashi Mashimo
Journal:  J Biomed Biotechnol       Date:  2011-03-07

6.  Adjunctive effect of the serotonin 5-HT2C receptor agonist lorcaserin on opioid-induced antinociception in mice.

Authors:  Salvador Sierra; Kumiko M Lippold; David L Stevens; Justin L Poklis; William L Dewey; Javier González-Maeso
Journal:  Neuropharmacology       Date:  2020-01-24       Impact factor: 5.273

Review 7.  Alternative RNA splicing: contribution to pain and potential therapeutic strategy.

Authors:  Lucy F Donaldson; Nicholas Beazley-Long
Journal:  Drug Discov Today       Date:  2016-06-18       Impact factor: 7.851

8.  5-HT₂ and 5-HT₇ receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons.

Authors:  Urszula Sławińska; Krzysztof Miazga; Larry M Jordan
Journal:  Front Neural Circuits       Date:  2014-08-19       Impact factor: 3.492
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.