Literature DB >> 1804563

Isolation of a new antitumor substance from Bacillus stearothermophilus.

Y Kohama1, T Teramoto, K Iida, N Murayama, T Semba, N Tatebatake, Y Kayamori, K Tsujikawa, T Mimura.   

Abstract

A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 micrograms/ml) and mouse mastocytoma, P-815 (IC50: 0.6 microgram/ml), but not that of Balb/c 3T3.

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Year:  1991        PMID: 1804563     DOI: 10.1248/cpb.39.2468

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  1 in total

Review 1.  Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.

Authors:  Robin K Pettit
Journal:  Mar Biotechnol (NY)       Date:  2010-05-01       Impact factor: 3.619

  1 in total

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