BACKGROUND: The link between psychosocial factors and coronary heart disease is well established, but although effects on coagulation and fibrinolysis variables may be implicated, no population-based study has sought to determine whether venous thromboembolism is similarly related to psychosocial factors. OBJECTIVE: To determine whether venous thromboembolism (deep vein thrombosis or pulmonary embolism) is related to psychosocial factors. PATIENTS/ METHODS: A stress questionnaire was filled in by 6958 men at baseline from 1970 to 1973, participants in a cardiovascular intervention trial. Their occupation was used to determine socio-economic status. RESULTS: After a maximum follow-up of 28.8 years, 358 cases of deep vein thrombosis and/or pulmonary embolism were identified through the Swedish hospital discharge and cause-specific death registries. In comparison with men who, at baseline, had no or moderate stress, men with persistent stress had increased risk of pulmonary embolism [hazard ratio (HR)=1.80, 95% CI: 1.21-2.67]. After multivariable adjustment, the HR decreased slightly to 1.66 (95% CI: 1.12-2.48). When compared with manual workers, men with white-collar jobs at intermediate or high level and professionals showed an inverse relationship between occupational class and pulmonary embolism (multiple-adjusted HR=0.57, 95% CI: 0.39-0.83). Deep vein thrombosis was not significantly related to either stress or occupational class. CONCLUSION: Both persistent stress and low occupational class were independently related to future pulmonary embolism. The mechanisms are unknown, but effects on coagulation and fibrinolytic factors are likely.
BACKGROUND: The link between psychosocial factors and coronary heart disease is well established, but although effects on coagulation and fibrinolysis variables may be implicated, no population-based study has sought to determine whether venous thromboembolism is similarly related to psychosocial factors. OBJECTIVE: To determine whether venous thromboembolism (deep vein thrombosis or pulmonary embolism) is related to psychosocial factors. PATIENTS/ METHODS: A stress questionnaire was filled in by 6958 men at baseline from 1970 to 1973, participants in a cardiovascular intervention trial. Their occupation was used to determine socio-economic status. RESULTS: After a maximum follow-up of 28.8 years, 358 cases of deep vein thrombosis and/or pulmonary embolism were identified through the Swedish hospital discharge and cause-specific death registries. In comparison with men who, at baseline, had no or moderate stress, men with persistent stress had increased risk of pulmonary embolism [hazard ratio (HR)=1.80, 95% CI: 1.21-2.67]. After multivariable adjustment, the HR decreased slightly to 1.66 (95% CI: 1.12-2.48). When compared with manual workers, men with white-collar jobs at intermediate or high level and professionals showed an inverse relationship between occupational class and pulmonary embolism (multiple-adjusted HR=0.57, 95% CI: 0.39-0.83). Deep vein thrombosis was not significantly related to either stress or occupational class. CONCLUSION: Both persistent stress and low occupational class were independently related to future pulmonary embolism. The mechanisms are unknown, but effects on coagulation and fibrinolytic factors are likely.
Authors: N S Roetker; S M Armasu; J S Pankow; P L Lutsey; W Tang; M A Rosenberg; T M Palmer; R F MacLehose; S R Heckbert; M Cushman; M de Andrade; A R Folsom Journal: J Thromb Haemost Date: 2017-06-06 Impact factor: 5.824
Authors: Bakhtawar K Mahmoodi; Mary Cushman; Inger Anne Næss; Matthew A Allison; Willem J Bos; Sigrid K Brækkan; Suzanne C Cannegieter; Ron T Gansevoort; Philimon N Gona; Jens Hammerstrøm; John-Bjarne Hansen; Susan Heckbert; Anders G Holst; Susan G Lakoski; Pamela L Lutsey; JoAnn E Manson; Lisa W Martin; Kunihiro Matsushita; Karina Meijer; Kim Overvad; Eva Prescott; Marja Puurunen; Jacques E Rossouw; Yingying Sang; Marianne T Severinsen; Jur Ten Berg; Aaron R Folsom; Neil A Zakai Journal: Circulation Date: 2016-11-09 Impact factor: 29.690
Authors: Nazim Isma; Juan Merlo; Henrik Ohlsson; Peter J Svensson; Bengt Lindblad; Anders Gottsäter Journal: J Thromb Thrombolysis Date: 2013-07 Impact factor: 2.300
Authors: M Blondon; K L Wiggins; B McKnight; B M Psaty; K M Rice; S R Heckbert; N L Smith Journal: Thromb Haemost Date: 2013-03-07 Impact factor: 5.249