Literature DB >> 18045156

"Sly as a FOXO": new paths with Forkhead signaling in the brain.

Kenneth Maiese1, Zhao Zhong Chong, Yan Chen Shang.   

Abstract

The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus erythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18045156      PMCID： PMC2570708          DOI： 10.2174/156720207782446306

Source DB:  PubMed          Journal:  Curr Neurovasc Res        ISSN： 1567-2026            Impact factor:   1.990


  129 in total

1.  Effects of nicotinamide on prevention and treatment of streptozotocin-induced diabetes mellitus in rats.

Authors:  Y Hu; Y Wang; L Wang; H Zhang; H Zhang; B Zhao; A Zhang; Y Li
Journal:  Chin Med J (Engl)       Date:  1996-11       Impact factor: 2.628

2.  Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.

Authors:  Diego H Castrillon; Lili Miao; Ramya Kollipara; James W Horner; Ronald A DePinho
Journal:  Science       Date:  2003-07-11       Impact factor: 47.728

Review 3.  Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury.

Authors:  Z Z Chong; F Li; K Maiese
Journal:  Histol Histopathol       Date:  2005-01       Impact factor: 2.303

4.  Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

Authors:  A Brunet; J Park; H Tran; L S Hu; B A Hemmings; M E Greenberg
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

5.  Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons.

Authors:  H Matsuzaki; M Tamatani; N Mitsuda; K Namikawa; H Kiyama; S Miyake; M Tohyama
Journal:  J Neurochem       Date:  1999-11       Impact factor: 5.372

6.  Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.

Authors:  T Furuyama; T Nakazawa; I Nakano; N Mori
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

7.  FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling.

Authors:  Wen-Hua Zheng; Satyabrata Kar; Rémi Quirion
Journal:  J Neurochem       Date:  2002-03       Impact factor: 5.372

8.  Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control.

Authors:  Yasutomi Kamei; Shinji Miura; Miki Suzuki; Yuko Kai; Junko Mizukami; Tomoyasu Taniguchi; Keiji Mochida; Tomoko Hata; Junichiro Matsuda; Hiroyuki Aburatani; Ichizo Nishino; Osamu Ezaki
Journal:  J Biol Chem       Date:  2004-07-21       Impact factor: 5.157

9.  Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats.

Authors:  T M Jackson; J M Rawling; B D Roebuck; J B Kirkland
Journal:  J Nutr       Date:  1995-06       Impact factor: 4.798

10.  Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK.

Authors:  Catherine Barthélémy; Christopher E Henderson; Brigitte Pettmann
Journal:  BMC Neurosci       Date:  2004-11-29       Impact factor: 3.288
View more
  57 in total

Review 1.  The "O" class: crafting clinical care with FoxO transcription factors.

Authors:  Kenneth Maiese; Zhao Zhong Chong; Jinling Hou; Yan Chen Shang
Journal:  Adv Exp Med Biol       Date:  2009       Impact factor: 2.622

Review 2.  Genetic studies reveal the role of the endocrine and metabolic systems in aging.

Authors:  Nir Barzilai; Ilan Gabriely; Gil Atzmon; Yousin Suh; Devorah Rothenberg; Aviv Bergman
Journal:  J Clin Endocrinol Metab       Date:  2010-10       Impact factor: 5.958

3.  Diabetic stress: new triumphs and challenges to maintain vascular longevity.

Authors:  Kenneth Maiese
Journal:  Expert Rev Cardiovasc Ther       Date:  2008-03

Review 4.  The Wnt signaling pathway: aging gracefully as a protectionist?

Authors:  Kenneth Maiese; Faqi Li; Zhao Zhong Chong; Yan Chen Shang
Journal:  Pharmacol Ther       Date:  2008-02-11       Impact factor: 12.310

5.  Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways.

Authors:  Zhao Zhong Chong; Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2008-08       Impact factor: 1.990

6.  Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation.

Authors:  Robert P Feehan; Lisa M Shantz
Journal:  Cell Signal       Date:  2016-04-04       Impact factor: 4.315

7.  Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia.

Authors:  Yan Chen Shang; Zhao Zhong Chong; Shaohui Wang; Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2013-02       Impact factor: 1.990

Review 8.  A "FOXO" in sight: targeting Foxo proteins from conception to cancer.

Authors:  Kenneth Maiese; Zhao Zhong Chong; Yan Chen Shang; Jinling Hou
Journal:  Med Res Rev       Date:  2009-05       Impact factor: 12.944

Review 9.  Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus.

Authors:  Kenneth Maiese
Journal:  Biomed Pharmacother       Date:  2008-02-20       Impact factor: 6.529

Review 10.  The vitamin nicotinamide: translating nutrition into clinical care.

Authors:  Kenneth Maiese; Zhao Zhong Chong; Jinling Hou; Yan Chen Shang
Journal:  Molecules       Date:  2009-09-09       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.