PURPOSE: In the highly active antiretroviral therapy (HAART) era, HIV-related diarrhea remains common. Our aim was to evaluate stool frequency and form as measures of HIV-related diarrhea. METHOD: Forty-eight HIV-infected persons with self-reported diarrhea were studied. In Analysis 1, self-reported retrospective and 7-day prospective measurement of stool frequency and form were compared using Spearman's correlation coefficient. In Analysis 2, diarrhea was measured during two 8-hour study periods in a subgroup (n = 20) using stool weight (Wt), diarrhea symptom score (Sx Score), stool frequency (SP-freq), and stool form using the Bristol Stool Form Scale (SP-BSFS). SP-freq and SP-BSFS were modeled alone and in combination to predict Wt and Sx Score. RESULTS: In Analysis 1, correlation between measures of stool frequency was rs = 0.62 (p < .0001) but was rs = 0.16 (p = .26) between measures of stool form. In Analysis 2, the two-predictor model best predicted Wt, whereas the model using SP-freq only performed as well as the two-predictor model to predict Sx Score. CONCLUSION: Prospective measurement of stool frequency performed well; in some situations, it may be used alone to measure severity of HIV-related diarrhea. Our findings may be used to design more rigorous clinical trials in HIV.
PURPOSE: In the highly active antiretroviral therapy (HAART) era, HIV-related diarrhea remains common. Our aim was to evaluate stool frequency and form as measures of HIV-related diarrhea. METHOD: Forty-eight HIV-infectedpersons with self-reported diarrhea were studied. In Analysis 1, self-reported retrospective and 7-day prospective measurement of stool frequency and form were compared using Spearman's correlation coefficient. In Analysis 2, diarrhea was measured during two 8-hour study periods in a subgroup (n = 20) using stool weight (Wt), diarrhea symptom score (Sx Score), stool frequency (SP-freq), and stool form using the Bristol Stool Form Scale (SP-BSFS). SP-freq and SP-BSFS were modeled alone and in combination to predict Wt and Sx Score. RESULTS: In Analysis 1, correlation between measures of stool frequency was rs = 0.62 (p < .0001) but was rs = 0.16 (p = .26) between measures of stool form. In Analysis 2, the two-predictor model best predicted Wt, whereas the model using SP-freq only performed as well as the two-predictor model to predict Sx Score. CONCLUSION: Prospective measurement of stool frequency performed well; in some situations, it may be used alone to measure severity of HIV-related diarrhea. Our findings may be used to design more rigorous clinical trials in HIV.
Authors: Bruno P Chumpitazi; Mariella M Lane; Danita I Czyzewski; Erica M Weidler; Paul R Swank; Robert J Shulman Journal: J Pediatr Date: 2010-06-17 Impact factor: 4.406
Authors: Kristen Aiemjoy; Eda Altan; Solomon Aragie; Dionna M Fry; Tung G Phan; Xutao Deng; Melsew Chanyalew; Zerihun Tadesse; E Kelly Callahan; Eric Delwart; Jeremy D Keenan Journal: BMC Infect Dis Date: 2019-01-14 Impact factor: 3.090