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Literature DB >> 180425

Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine.

Abstract

The 5'-terminus 7-methylguanosine of vesicular stomatitis virus mRNA is not essential for translation of the mRNA. The 7-methylguanosine seems to have a mediating rather than an obligatory role in ribosome binding by the mRNA and in mRNA translation.

Entities: Chemical Species

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Year: 1976 PMID： 180425 DOI： 10.1038/262032a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

35 in total

1. Capped mRNAs with reduced secondary structure can function in extracts from poliovirus-infected cells.

Authors: N Sonenberg; D Guertin; K A Lee
Journal: Mol Cell Biol Date: 1982-12 Impact factor: 4.272

2. Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.

Authors: K Shimotohno; Y Kodama; J Hashimoto; K I Miura
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

3. Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.

Authors: J B Flanegan; R F Petterson; V Ambros; N J Hewlett; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1977-03 Impact factor: 11.205

Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine.

1. Capped mRNAs with reduced secondary structure can function in extracts from poliovirus-infected cells.

2. Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.

3. Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.

4. Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein.

5. Nucleotide sequences of ribosome recgonition sites in messenger RNAs of vesicular stomatitis virus.

6. Small nuclear RNAs in the ciliate Tetrahymena.

7. Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

8. mRNA poly(A) tail, a 3' enhancer of translational initiation.

9. Removal of 5'-terminal m7G from eukaryotic mRNAs by potato nucleotide pyrophosphatase and its effect on translation.

10. Specific inhibition of capped mRNA translation in vitro by m7G5'pppp5'G and m7G5'pppp5'm7G.