Literature DB >> 18040664

Optimising islet engraftment is critical for successful clinical islet transplantation.

O Korsgren1, T Lundgren, M Felldin, A Foss, B Isaksson, J Permert, N H Persson, E Rafael, M Rydén, K Salmela, A Tibell, G Tufveson, B Nilsson.   

Abstract

Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.

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Year:  2007        PMID： 18040664     DOI： 10.1007/s00125-007-0868-9

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  48 in total

1.  Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?

Authors:  M Koulmanda; R N Smith; A Qipo; G Weir; H Auchincloss; T B Strom
Journal:  Am J Transplant       Date:  2006-04       Impact factor: 8.086

2.  Transplantation of the parathyroid glands in man: clinical indications and results.

Authors:  S A Wells; J C Gunnells; J D Shelburne; A B Schneider; L M Sherwood
Journal:  Surgery       Date:  1975-07       Impact factor: 3.982

3.  DNA replication in mouse pancreatic islets transplanted subcapsularly into the kidney or intraportally into the liver. Influence of unilateral nephrectomy or partial hepatectomy.

Authors:  A Dunger; O Korsgren; A Andersson
Journal:  Transplantation       Date:  1990-04       Impact factor: 4.939

4.  Intraportally transplanted pancreatic islets revascularized from hepatic arterial system.

Authors:  A Andersson; O Korsgren; L Jansson
Journal:  Diabetes       Date:  1989-01       Impact factor: 9.461

5.  Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients.

Authors:  Corine A van Kampen; Pieter van de Linde; Gaby Duinkerken; Jolien J van Schip; Dave L Roelen; Bart Keymeulen; Daniel G Pipeleers; Frans H J Claas; Bart O Roep
Journal:  Transplantation       Date:  2005-07-15       Impact factor: 4.939

6.  Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats.

Authors:  C B Kemp; M J Knight; D W Scharp; W F Ballinger; P E Lacy
Journal:  Diabetologia       Date:  1973-12       Impact factor: 10.122

7.  Islets transplanted intraportally into the liver are stimulated to insulin and glucagon release exclusively through the hepatic artery.

Authors:  J Lau; L Jansson; P-O Carlsson
Journal:  Am J Transplant       Date:  2006-05       Impact factor: 8.086

8.  Islet autotransplantation after left pancreatectomy for non-enucleable insulinoma.

Authors:  José Oberholzer; Zoltan Mathe; Pascal Bucher; Fréderic Triponez; Domenico Bosco; Béatrice Fournier; Pietro Majno; Jacques Philippe; Philippe Morel
Journal:  Am J Transplant       Date:  2003-10       Impact factor: 8.086

9.  Induction and quantification of hepatic metastases from a human colonic cancer in the nude rat.

Authors:  W Graf; A Sundin; B Glimelius; H Ahlström; J Carlsson
Journal:  Eur J Surg Oncol       Date:  1992-12       Impact factor: 4.424

10.  Long-term reversal of streptozotocin-induced diabetes in rats by intramuscular islet implantation.

Authors:  K V Axen; F X Pi-Sunyer
Journal:  Transplantation       Date:  1981-06       Impact factor: 4.939
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  54 in total

1.  Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel.

Authors:  Dong-Jin Lim; Sergey V Antipenko; Joel M Anderson; Kimberly F Jaimes; Liliana Viera; Bradley R Stephen; Stacie M J Bryant; Brett D Yancey; Katherine J Hughes; Wanxing Cui; John A Thompson; John A Corbett; Ho-Wook Jun
Journal:  Tissue Eng Part A       Date:  2010-10-19       Impact factor: 3.845

2.  Monitoring neovascularization of intraportal islet grafts by dynamic contrast enhanced magnetic resonance imaging.

Authors:  Nathaniel K Chan; Andre Obenaus; Annie Tan; Naoaki Sakata; John Mace; Ricardo Peverini; Richard Chinnock; Lawrence C Sowers; Eba Hathout
Journal:  Islets       Date:  2009-11       Impact factor: 2.694

Review 3.  The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.

Authors:  Stanley Misler
Journal:  Islets       Date:  2010 Jul-Aug       Impact factor: 2.694

Review 4.  State of the art of clinical islet transplantation and novel protocols of immunosuppression.

Authors:  A M James Shapiro
Journal:  Curr Diab Rep       Date:  2011-10       Impact factor: 4.810

5.  Preculturing Islets With Adipose-Derived Mesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site.

Authors:  Chloe L Rackham; Paramjeet K Dhadda; Aurélie M Le Lay; Aileen J F King; Peter M Jones
Journal:  Cell Med       Date:  2014-03-24

6.  The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.

Authors:  H Scholz; T Lund; M K Dahle; J L Collins; O Korsgren; J E Wang; A Foss
Journal:  Diabetologia       Date:  2009-05-05       Impact factor: 10.122

7.  Current status of clinical islet transplantation.

Authors:  Andrew R Pepper; Boris Gala-Lopez; Oliver Ziff; Am James Shapiro
Journal:  World J Transplant       Date:  2013-12-24

8.  Benefits of PEGylation in the early post-transplant period of intraportal islet transplantation as assessed by magnetic resonance imaging of labeled islets.

Authors:  Sang-Man Jin; Seung-Hoon Oh; Bae Jun Oh; Sunghwan Suh; Ji Cheol Bae; Jung Hee Lee; Myung-Shik Lee; Moon-Kyu Lee; Kwang-Won Kim; Jae Hyeon Kim
Journal:  Islets       Date:  2014       Impact factor: 2.694

Review 9.  Adipose stem cell-based regenerative medicine for reversal of diabetic hyperglycemia.

Authors:  Hyun Joon Paek; Courtney Kim; Stuart K Williams
Journal:  World J Diabetes       Date:  2014-06-15

10.  Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets.

Authors:  C Krautz; S Wolk; A Steffen; K-P Knoch; U Ceglarek; J Thiery; S Bornstein; H-D Saeger; M Solimena; S Kersting
Journal:  Diabetologia       Date:  2013-03-27       Impact factor: 10.122
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