Relationship between topological properties and biological activity of platinum (II) complexes.

A graph-theoretical method is applied to model of the relations between structure and biological activity of the anticancer Pt(II) complexes. Values of LD50, ID90, TI and % of ILS resulted from the treatment of animals bearing experimentalis ADJ/PC6 or L1210 tumors, available in the literature, were used as parameters characterizing the antitumor activity of platinum complexes. The results indicate that it is possible to find a topological description of these complexes which could be useful in their structure - activity investigations.