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Literature DB >> 18039887

Drosophila G9a is a nonessential gene.

Carole Seum¹, Séverine Bontron, Emanuela Reo, Marion Delattre, Pierre Spierer.

Abstract

Mammalian G9a is a euchromatic histone H3 lysine 9 (H3K9) methyltransferase essential for development. Here, we characterize the Drosophila homolog of G9a, dG9a. We generated a dG9a deletion allele by homologous recombination. Analysis of this allele revealed that, in contrast to recent findings, dG9a is not required for fly viability.

Entities: Gene Species

Mesh：

Substances：

Year: 2007 PMID： 18039887 PMCID： PMC2147950 DOI： 10.1534/genetics.107.078220

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

16 in total

1. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3.

Authors: S A Jacobs; S D Taverna; Y Zhang; S D Briggs; J Li; J C Eissenberg; C D Allis; S Khorasanizadeh
Journal: EMBO J Date: 2001-09-17 Impact factor: 11.598

2. Ends-out, or replacement, gene targeting in Drosophila.

Authors: Wei J Gong; Kent G Golic
Journal: Proc Natl Acad Sci U S A Date: 2003-02-14 Impact factor: 11.205

3. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.

Authors: Judd C Rice; Scott D Briggs; Beatrix Ueberheide; Cynthia M Barber; Jeffrey Shabanowitz; Donald F Hunt; Yoichi Shinkai; C David Allis
Journal: Mol Cell Date: 2003-12 Impact factor: 17.970

4. Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.

Authors: Avtar Roopra; Romena Qazi; Barry Schoenike; Timothy J Daley; John F Morrison
Journal: Mol Cell Date: 2004-06-18 Impact factor: 17.970

5. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

Authors: M Lachner; D O'Carroll; S Rea; K Mechtler; T Jenuwein
Journal: Nature Date: 2001-03-01 Impact factor: 49.962

6. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.

Authors: M Tachibana; K Sugimoto; T Fukushima; Y Shinkai
Journal: J Biol Chem Date: 2001-04-20 Impact factor: 5.157

7. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.

Authors: Gunnar Schotta; Anja Ebert; Veiko Krauss; Andreas Fischer; Jan Hoffmann; Stephen Rea; Thomas Jenuwein; Rainer Dorn; Gunter Reuter
Journal: EMBO J Date: 2002-03-01 Impact factor: 11.598

Review 8. SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing.

Authors: Gunnar Schotta; Anja Ebert; Gunter Reuter
Journal: Genetica Date: 2003-03 Impact factor: 1.082

9. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.

Authors: Makoto Tachibana; Kenji Sugimoto; Masami Nozaki; Jun Ueda; Tsutomu Ohta; Misao Ohki; Mikiko Fukuda; Naoki Takeda; Hiroyuki Niida; Hiroyuki Kato; Yoichi Shinkai
Journal: Genes Dev Date: 2002-07-15 Impact factor: 11.361

10. Drosophila SETDB1 is required for chromosome 4 silencing.

Authors: Carole Seum; Emanuela Reo; Hongzhuang Peng; Frank J Rauscher; Pierre Spierer; Séverine Bontron
Journal: PLoS Genet Date: 2007-05-11 Impact factor: 5.917

19 in total

Review 1. SET for life: biochemical activities and biological functions of SET domain-containing proteins.

Authors: Hans-Martin Herz; Alexander Garruss; Ali Shilatifard
Journal: Trends Biochem Sci Date: 2013-10-20 Impact factor: 13.807

2. A major epigenetic programming mechanism guided by piRNAs.

Authors: Xiao A Huang; Hang Yin; Sarah Sweeney; Debasish Raha; Michael Snyder; Haifan Lin
Journal: Dev Cell Date: 2013-02-21 Impact factor: 12.270

3. Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis.

Authors: Yuta Ushijima; Yoshihiro H Inoue; Takahiro Konishi; Daishi Kitazawa; Hideki Yoshida; Kouhei Shimaji; Hiroshi Kimura; Masamitsu Yamaguchi
Journal: Chromosome Res Date: 2012-04-05 Impact factor: 5.239

4. Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1.

Authors: Emily Clough; Thomas Tedeschi; Tulle Hazelrigg
Journal: Dev Biol Date: 2014-01-28 Impact factor: 3.582

5. Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates.

Authors: Lei Wang; Bernard Charroux; Stephen Kerridge; Chih-Cheng Tsai
Journal: EMBO Rep Date: 2008-05-02 Impact factor: 8.807

6. Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.

Authors: Brent Brower-Toland; Nicole C Riddle; Hongmei Jiang; Kathryn L Huisinga; Sarah C R Elgin
Journal: Genetics Date: 2009-02-02 Impact factor: 4.562

10. Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.

Authors: Carmen M Koch; Mona Honemann-Capito; Diane Egger-Adam; Andreas Wodarz
Journal: PLoS Genet Date: 2009-09-11 Impact factor: 5.917