| Literature DB >> 18039577 |
Mary Mader1, Alfonso de Dios, Chuan Shih, Rosanne Bonjouklian, Tiechao Li, Wesley White, Beatriz López de Uralde, Concepción Sánchez-Martinez, Miriam del Prado, Carlos Jaramillo, Eugenio de Diego, Luisa M Martín Cabrejas, Carmen Dominguez, Carlos Montero, Timothy Shepherd, Robert Dally, John E Toth, Arindam Chatterjee, Sehila Pleite, Jaime Blanco-Urgoiti, Leticia Perez, Mario Barberis, María José Lorite, Enrique Jambrina, C Richard Nevill, Paul A Lee, Richard C Schultz, Jeffrey A Wolos, Li C Li, Robert M Campbell, Bryan D Anderson.
Abstract
Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as well, resulting in compounds possessing cellular potency and enhanced in vivo activity in the rat collagen-induced arthritis model of chronic inflammation.Entities:
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Year: 2007 PMID： 18039577 DOI： 10.1016/j.bmcl.2007.10.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823