Literature DB >> 18039412

UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health.

John C Stanley1, Rachel L Elsom, Philip C Calder, Bruce A Griffin, William S Harris, Susan A Jebb, Julie A Lovegrove, Carmel S Moore, Rudolph A Riemersma, Tom A B Sanders.   

Abstract

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 11 September 2006 to review the results of three FSA-funded studies and other recent research on effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health. The objective of this workshop was to reach a clear conclusion on whether or not it was worth funding any further research in this area. On the basis of this review of the experimental evidence and on theoretical grounds, it was concluded that the n-6:n-3 fatty acid ratio is not a useful concept and that it distracts attention away from increasing absolute intakes of long-chain n-3 fatty acids which have been shown to have beneficial effects on cardiovascular health. Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful.

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Year:  2007        PMID: 18039412      PMCID: PMC2755100          DOI: 10.1017/S000711450784284X

Source DB:  PubMed          Journal:  Br J Nutr        ISSN: 0007-1145            Impact factor:   3.718


  41 in total

1.  Total fat intake modifies plasma fatty acid composition in humans.

Authors:  S K Raatz; D Bibus; W Thomas; P Kris-Etherton
Journal:  J Nutr       Date:  2001-02       Impact factor: 4.798

2.  Dietary fat intake and proinflammatory cytokine levels in patients with heart failure.

Authors:  Terry A Lennie; Misook L Chung; Diane L Habash; Debra K Moser
Journal:  J Card Fail       Date:  2005-10       Impact factor: 5.712

3.  Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population-based cross-sectional study.

Authors:  T Tillin; N Forouhi; D G Johnston; P M McKeigue; N Chaturvedi; I F Godsland
Journal:  Diabetologia       Date:  2005-03-10       Impact factor: 10.122

4.  Diet, serum cholesterol, and death from coronary heart disease. The Western Electric study.

Authors:  R B Shekelle; A M Shryock; O Paul; M Lepper; J Stamler; S Liu; W J Raynor
Journal:  N Engl J Med       Date:  1981-01-08       Impact factor: 91.245

5.  Dietary fat intake and the risk of coronary heart disease in women.

Authors:  F B Hu; M J Stampfer; J E Manson; E Rimm; G A Colditz; B A Rosner; C H Hennekens; W C Willett
Journal:  N Engl J Med       Date:  1997-11-20       Impact factor: 91.245

6.  Maintenance of lower proportions of (n - 6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n - 3) fatty acids.

Authors:  W E Lands; B Libelt; A Morris; N C Kramer; T E Prewitt; P Bowen; D Schmeisser; M H Davidson; J H Burns
Journal:  Biochim Biophys Acta       Date:  1992-12-10

7.  Moderate fish-oil supplementation reverses low-platelet, long-chain n-3 polyunsaturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians.

Authors:  Julie A Lovegrove; Sean S Lovegrove; Stephanie V M Lesauvage; Louise M Brady; Nicky Saini; Anne M Minihane; Christine M Williams
Journal:  Am J Clin Nutr       Date:  2004-06       Impact factor: 7.045

8.  Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women.

Authors:  Tobias Pischon; Susan E Hankinson; Gökhan S Hotamisligil; Nader Rifai; Walter C Willett; Eric B Rimm
Journal:  Circulation       Date:  2003-06-23       Impact factor: 29.690

9.  Dietary alpha-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans.

Authors:  D S Kelley; G J Nelson; J E Love; L B Branch; P C Taylor; P C Schmidt; B E Mackey; J M Iacono
Journal:  Lipids       Date:  1993-06       Impact factor: 1.880

Review 10.  Reduced or modified dietary fat for preventing cardiovascular disease.

Authors:  L Hooper; C D Summerbell; J P Higgins; R L Thompson; G Clements; N Capps; S Davey; R A Riemersma; S Ebrahim
Journal:  Cochrane Database Syst Rev       Date:  2001
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  23 in total

1.  The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease.

Authors:  Joann E Manson; Shari S Bassuk; I-Min Lee; Nancy R Cook; Michelle A Albert; David Gordon; Elaine Zaharris; Jean G Macfadyen; Eleanor Danielson; Jennifer Lin; Shumin M Zhang; Julie E Buring
Journal:  Contemp Clin Trials       Date:  2011-10-02       Impact factor: 2.226

2.  Effects of postnatal overfeeding and fish oil diet on energy expenditure in rats.

Authors:  Yanyan Dai; Nan Zhou; Fan Yang; Shanshan Zhou; Lijun Sha; Jianping Wang; Xiaonan Li
Journal:  Pediatr Res       Date:  2017-10-04       Impact factor: 3.756

3.  The effects of slaughter weight on chemical composition, physical properties, and fatty acid profile of musculus longissimus dorsi in Holstein bulls.

Authors:  Ertuğrul Kul; Aziz Şahin; Yüksel Aksoy; Emre Uğurlutepe
Journal:  Trop Anim Health Prod       Date:  2019-07-06       Impact factor: 1.559

4.  Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio.

Authors:  Mark K Waldron; Steven S Hannah; John E Bauer
Journal:  Lipids       Date:  2012-01-18       Impact factor: 1.880

5.  Polyunsaturated fatty acids and cardiovascular disease.

Authors:  Doriane Richard; Pedro Bausero; Charlotte Schneider; Francesco Visioli
Journal:  Cell Mol Life Sci       Date:  2009-07-10       Impact factor: 9.261

6.  Circulating Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Painful Temporomandibular Disorder and Low Back Pain.

Authors:  Anne E Sanders; E Diane Weatherspoon; Brandie M Ehrmann; Paul S Soma; Saame R Shaikh; John S Preisser; Richard Ohrbach; Roger B Fillingim; Gary D Slade
Journal:  J Pain       Date:  2022-06-10       Impact factor: 5.383

Review 7.  Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association.

Authors:  Majid Fotuhi; Payam Mohassel; Kristine Yaffe
Journal:  Nat Clin Pract Neurol       Date:  2009-03

8.  Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes?

Authors:  Robert C Block; William S Harris; Kimberly J Reid; John A Spertus
Journal:  Am Heart J       Date:  2008-10-14       Impact factor: 4.749

9.  Development of rabbit meat products fortified with n-3 polyunsaturated fatty acids.

Authors:  Massimiliano Petracci; Maurizio Bianchi; Claudio Cavani
Journal:  Nutrients       Date:  2009-10-20       Impact factor: 6.706

Review 10.  Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions.

Authors:  Philip C Calder; Gordon L Jensen; Berthold V Koletzko; Pierre Singer; Geert J A Wanten
Journal:  Intensive Care Med       Date:  2010-01-14       Impact factor: 17.440

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