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Literature DB >> 18039134

Airway smooth muscle in asthma.

Marc B Hershenson¹, Melanie Brown, Blanca Camoretti-Mercado, Julian Solway.

Abstract

Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review the current understanding of the contribution of airway myocytes to airway inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome. Together, these roles make airway smooth muscle an attractive target for asthma therapy.

Entities: Disease

Mesh：

Year: 2008 PMID： 18039134 DOI： 10.1146/annurev.pathmechdis.1.110304.100213

Source DB: PubMed Journal: Annu Rev Pathol ISSN： 1553-4006 Impact factor: 23.472

Keyword Cloud
Cited

39 in total

1. Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.

Authors: Zhao Yang; Philip R Cooper; Gautam Damera; Indranil Mukhopadhyay; Hyeseon Cho; John H Kehrl; Reynold A Panettieri; Kirk M Druey
Journal: J Biol Chem Date: 2011-01-29 Impact factor: 5.157

Review 2. Does airway smooth muscle express an inflammatory phenotype in asthma?

Authors: Gautam Damera; Reynold A Panettieri
Journal: Br J Pharmacol Date: 2011-05 Impact factor: 8.739

3. Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

Authors: Zhao Yang; Nariman Balenga; Philip R Cooper; Gautam Damera; Richard Edwards; Christopher E Brightling; Reynold A Panettieri; Kirk M Druey
Journal: Am J Respir Cell Mol Biol Date: 2012-01-26 Impact factor: 6.914

4. An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.

Authors: Aruna Ramachandran; Sandeep A Ranpura; Edward M Gong; Michelle Mulone; Glenn M Cannon; Rosalyn M Adam
Journal: Am J Pathol Date: 2010-05-14 Impact factor: 4.307

5. Asthma and sarcoplasmic reticulum Ca2+ reuptake in airway smooth muscle.

Authors: Y S Prakash; Venkatachalem Sathish; Michael A Thompson; Christina M Pabelick; Gary C Sieck
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2009-10 Impact factor: 5.464

6. Myosin light chain kinase is necessary for tonic airway smooth muscle contraction.

Authors: Wen-Cheng Zhang; Ya-Jing Peng; Gen-Sheng Zhang; Wei-Qi He; Yan-Ning Qiao; Ying-Ying Dong; Yun-Qian Gao; Chen Chen; Cheng-Hai Zhang; Wen Li; Hua-Hao Shen; Wen Ning; Kristine E Kamm; James T Stull; Xiang Gao; Min-Sheng Zhu
Journal: J Biol Chem Date: 2009-12-14 Impact factor: 5.157

Airway smooth muscle in asthma.

1. Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.

Review 2. Does airway smooth muscle express an inflammatory phenotype in asthma?

3. Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

4. An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.

5. Asthma and sarcoplasmic reticulum Ca2+ reuptake in airway smooth muscle.

6. Myosin light chain kinase is necessary for tonic airway smooth muscle contraction.

7. Studies on expression and function of the TMEM16A calcium-activated chloride channel.

8. YAP is up-regulated in the bronchial airway smooth muscle of the chronic asthma mouse model.

9. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model.

Review 10. Targeting the airway smooth muscle for asthma treatment.