| Literature DB >> 18038968 |
Michael G Bell1, Douglas L Gernert, Timothy A Grese, Matthew D Belvo, Peter S Borromeo, Sally A Kelley, Joseph H Kennedy, Stanley P Kolis, Peter A Lander, Rachel Richey, V Scott Sharp, Gregory A Stephenson, Jeffrey D Williams, Hannah Yu, Karen M Zimmerman, Mitchell I Steinberg, Prabhakar K Jadhav.
Abstract
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lowering at pharmaceutically relevant doses.Entities:
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Year: 2007 PMID： 18038968 DOI： 10.1021/jm701186z
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446