Literature DB >> 18038235

Unsuspected breast carcinoma presenting as orbital complication of rhinosinusitis.

G Fyrmpas1, D Televantou, V Papageorgiou, F Nofal, J Constantinidis.   

Abstract

We report a rare clinical presentation of breast carcinoma metastasis to the ethmoid sinuses, orbit and cavernous sinus in a 70-year-old lady with unsuspected breast carcinoma who presented with clinical features of acute ethmoiditis, orbital cellulitis and cavernous sinus thrombosis. The patient underwent endoscopic ethmoidectomy and histology of the necrotic tissue from the ethmoidal cells was positive for endovascular neoplastic emboli. Subsequent examination revealed a large mass in the left breast, tethered to the skin, which was histologically confirmed to be a carcinoma. The patient died 2 months post-diagnosis. To our knowledge, this is the third case manifesting with combined features of ethmoiditis, orbital cellulitis and cavernous sinus syndrome from an unsuspected breast carcinoma. This case highlights the importance of imaging and thorough physical examination when a dramatic clinical picture presents in the paranasal sinuses of an otherwise healthy individual. Such manifestation of breast carcinoma is difficult to diagnose, and therefore, a high index of suspicion should be maintained. Skull base metastases from breast carcinoma behave aggressively and if diagnosed early, treatment may prolong survival and improve quality of life.

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Year:  2007        PMID: 18038235     DOI: 10.1007/s00405-007-0540-5

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN: 0937-4477            Impact factor:   2.503


  12 in total

Review 1.  Symmetrical ethmoidal metastases from ductal carcinoma of the breast, suggesting transcribrosal spread.

Authors:  D Monserez; S Vlaminck; R Kuhweide; J Casselman
Journal:  Acta Otorhinolaryngol Belg       Date:  2001

2.  Case report. Severe cutaneous ulceration secondary to cytomegalovirus inclusion disease during successful immune reconstitution with HAART.

Authors:  Nadeem A Qazi; John F Morlese; John C Walsh; Christopher B Bunker; Nicholas Francis; Mark R Nelson
Journal:  AIDS Read       Date:  2002-10

Review 3.  Skull-base metastases.

Authors:  Florence Laigle-Donadey; Sophie Taillibert; Nadine Martin-Duverneuil; Jerzy Hildebrand; Jean-Yves Delattre
Journal:  J Neurooncol       Date:  2005-10       Impact factor: 4.130

4.  Cytomegalovirus retinitis and optic neuritis in a child with severe combined immunodeficiency syndrome.

Authors:  B A Perren; J Raisanen; W V Good; J B Crawford
Journal:  Retina       Date:  1996       Impact factor: 4.256

5.  Occipital condyle syndrome.

Authors:  David J Capobianco; Paul W Brazis; Frank A Rubino; Jon N Dalton
Journal:  Headache       Date:  2002-02       Impact factor: 5.887

6.  Breast cancer metastasis presenting as ethmoiditis.

Authors:  A Pitkäranta; A Markkola; H Malmberg
Journal:  Rhinology       Date:  2001-06       Impact factor: 3.681

Review 7.  [Metastases to the paranasal sinuses: case report and review of the literature].

Authors:  A Prescher; D Brors
Journal:  Laryngorhinootologie       Date:  2001-10       Impact factor: 1.057

Review 8.  Breast carcinoma metastatic to paranasal sinuses.

Authors:  J R Austin; M M Kershiznek; D McGill; S G Austin
Journal:  Head Neck       Date:  1995 Mar-Apr       Impact factor: 3.147

9.  Metastasis to the base of the skull: clinical findings in 43 patients.

Authors:  H S Greenberg; M D Deck; B Vikram; F C Chu; J B Posner
Journal:  Neurology       Date:  1981-05       Impact factor: 9.910

10.  Metastatic tumors in the sellar and parasellar regions: clinical review of four cases.

Authors:  H J Yi; C H Kim; K H Bak; J M Kim; Y Ko; S J Oh
Journal:  J Korean Med Sci       Date:  2000-06       Impact factor: 2.153

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  9 in total

1.  [Breast cancer metastases in the head and neck region].

Authors:  P J Schuler; S Heikaus; U Friebe-Hoffmann; T K Hoffmann; J Greve; T Klenzner; J Schipper; K Scheckenbach
Journal:  HNO       Date:  2010-08       Impact factor: 1.284

2.  Distant metastases to nasal cavities and paranasal sinuses case series.

Authors:  N Azarpira; M J Ashraf; B Khademi; N Asadi
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  2011-05-15

3.  Ptosis due to cavernous sinus syndrome as a rare presentation of advanced breast metastasis in a patient with delayed diagnosis.

Authors:  Kw Khaw; N Ramli; K Rahmat
Journal:  Malays Fam Physician       Date:  2012-04-30

4.  Ethmoidal metastasis as a first presentation of breast cancer: a case report.

Authors:  A Maity; E Maughan; S Vasani; G Alusi
Journal:  Ann R Coll Surg Engl       Date:  2018-04-01       Impact factor: 1.891

5.  Paranasal sinus metastasis of breast cancer.

Authors:  P Pittoni; S Di Lascio; M Conti-Beltraminelli; M C Valli; V Espeli; M Bongiovanni; A Richetti; O Pagani
Journal:  BMJ Case Rep       Date:  2014-06-27

6.  Orbital metastasis of breast carcinoma.

Authors:  Panagiotis J Vlachostergios; Ioannis A Voutsadakis; Christos N Papandreou
Journal:  Breast Cancer (Auckl)       Date:  2009-12-02

7.  Breast Cancer Metastases of the Left Occipital Condyle Diagnosed through Extended Mastoidectomy: Case Report.

Authors:  Peter Valentin Tomazic; Thorsten Ropposch; Ulrike Nemetz; Christian Walch
Journal:  Skull Base Rep       Date:  2011-03-15

8.  Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis.

Authors:  Mayara Tabai; Igor Moreira Hazboun; Emerson Taro Inoue Sakuma; Marcelo Hamilton Sampaio; Eulalia Sakano
Journal:  Case Rep Otolaryngol       Date:  2016-08-01

Review 9.  Rare sites of breast cancer metastasis: a review.

Authors:  Rosa Di Micco; Letizia Santurro; Maria Luisa Gasparri; Veronica Zuber; Enrico Fiacco; Guglielmo Gazzetta; Chanel Elisha Smart; Alice Valentini; Oreste Davide Gentilini
Journal:  Transl Cancer Res       Date:  2019-10       Impact factor: 1.241

  9 in total

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