Literature DB >> 18038151

The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan.

Thoraya M E A-Elgadir1, Mustafa I Elbashir, Klavs Berzins, Emad M Masuadi, Ishraga E A-Elbasit, Gehad ElGhazali, Hayder A Giha.   

Abstract

In this study, antibodies (Ab) directed against three MSP antigens; MSP1(19), MSP2(A), and MSP2(B) were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P<0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P=0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.

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Year:  2007        PMID： 18038151     DOI： 10.1007/s00436-007-0777-3

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  28 in total

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Journal:  Trans R Soc Trop Med Hyg       Date:  2000-04       Impact factor: 2.184

2.  A Plasmodium falciparum MSA-2 gene apparently generated by intragenic recombination between the two allelic families.

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Journal:  Mol Biochem Parasitol       Date:  1991-04       Impact factor: 1.759

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Journal:  Trans R Soc Trop Med Hyg       Date:  1999-02       Impact factor: 2.184

4.  Assessment of the role of naturally acquired antibody levels to Plasmodium falciparum merozoite surface protein-1 in protecting Papua New Guinean children from malaria morbidity.

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Journal:  Am J Trop Med Hyg       Date:  1996-05       Impact factor: 2.345

5.  IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria.

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Journal:  Am J Trop Med Hyg       Date:  1998-04       Impact factor: 2.345

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Journal:  Prog Allergy       Date:  1988

7.  Clinical pattern of severe Plasmodium falciparum malaria in Sudan in an area characterized by seasonal and unstable malaria transmission.

Authors:  H A Giha; G Elghazali; T M E A-Elgadir; I E A-Elbasit; E M Eltahir; O Z Baraka; M M Khier; I Adam; M Troye-Blomberg; T G Theander; M I Elbashir
Journal:  Trans R Soc Trop Med Hyg       Date:  2005-04       Impact factor: 2.184

8.  Serum IgG3 to the Plasmodium falciparum merozoite surface protein 2 is strongly associated with a reduced prospective risk of malaria.

Authors:  Wolfram G Metzger; Daniel M N Okenu; David R Cavanagh; Jane V Robinson; Kalifa A Bojang; Helen A Weiss; Jana S McBride; Brian M Greenwood; David J Conway
Journal:  Parasite Immunol       Date:  2003-06       Impact factor: 2.280

9.  Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity.

Authors:  E M Riley; S J Allen; J G Wheeler; M J Blackman; S Bennett; B Takacs; H J Schönfeld; A A Holder; B M Greenwood
Journal:  Parasite Immunol       Date:  1992-05       Impact factor: 2.280

10.  Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein.

Authors:  M J Blackman; T J Scott-Finnigan; S Shai; A A Holder
Journal:  J Exp Med       Date:  1994-07-01       Impact factor: 14.307
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  3 in total

1.  Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria.

Authors:  Hodan Ahmed Ismail; Ulf Ribacke; Linda Reiling; Johan Normark; Tom Egwang; Fred Kironde; James G Beeson; Mats Wahlgren; Kristina E M Persson
Journal:  Clin Vaccine Immunol       Date:  2013-06-05

2.  Genome-wide identification and functional annotation of Plasmodium falciparum long noncoding RNAs from RNA-seq data.

Authors:  Qi Liao; Jia Shen; Jianfa Liu; Xi Sun; Guoguang Zhao; Yanzi Chang; Leiting Xu; Xuerong Li; Ya Zhao; Huanqin Zheng; Yi Zhao; Zhongdao Wu
Journal:  Parasitol Res       Date:  2014-02-13       Impact factor: 2.289

3.  Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria.

Authors:  Fabiana M S Leoratti; Rui R Durlacher; Marcus V G Lacerda; Maria G Alecrim; Antonio W Ferreira; Maria C A Sanchez; Sandra L Moraes
Journal:  Malar J       Date:  2008-09-24       Impact factor: 2.979
  3 in total

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