| Literature DB >> 18037886 |
Henri L Saenz1, Philipp Engel, Michèle C Stoeckli, Christa Lanz, Günter Raddatz, Muriel Vayssier-Taussat, Richard Birtles, Stephan C Schuster, Christoph Dehio.
Abstract
The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.Entities:
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Year: 2007 PMID： 18037886 DOI： 10.1038/ng.2007.38
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330