Literature DB >> 18037380

A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion.

Débora M Portilho1, Eliane R Martins, Manoel L Costa, Cláudia S Mermelstein.   

Abstract

Cholesterol is one of the major lipids of plasma membranes. Recently, we have shown that cholesterol depletion by methyl-beta-cyclodextrin (M beta CD) induces the activation of the Wnt/beta-catenin pathway and enhances myogenic differentiation. Here, we show that M beta CD-conditioned media accelerates myogenesis in a similar way as M beta CD does, suggesting that the effects induced by M beta CD could be caused by soluble factors present in the culture medium. Soluble Wnt-3 protein is significantly enhanced in M beta CD-conditioned medium. Wnt-3a-enriched media induces myogenesis as much as M beta CD does, whereas Wnt-5a-enriched media inhibits. We suggest that Wnt-3a is involved in the myogenic induction observed after cholesterol depletion.

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Year:  2007        PMID： 18037380     DOI： 10.1016/j.febslet.2007.11.047

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Isolation and characterization of recombinant murine Wnt3a.

Authors:  Andrzej Witkowski; Aparna Krishnamoorthy; Betty Su; Jennifer A Beckstead; Robert O Ryan
Journal:  Protein Expr Purif       Date:  2014-11-08       Impact factor: 1.650

2.  Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.

Authors:  David S Paek; Reiko Sakurai; Aditi Saraswat; Yishi Li; Omid Khorram; John S Torday; Virender K Rehan
Journal:  Reprod Sci       Date:  2014-06-10       Impact factor: 3.060

3.  Cholesterol depletion induces transcriptional changes during skeletal muscle differentiation.

Authors:  Ana C B Possidonio; Milene Miranda; Gustavo B Gregoracci; Fabiano L Thompson; Manoel L Costa; Claudia Mermelstein
Journal:  BMC Genomics       Date:  2014-06-30       Impact factor: 3.969

4.  PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells.

Authors:  Danielle C Bonfim; Rhayra B Dias; Anneliese Fortuna-Costa; Leonardo Chicaybam; Daiana V Lopes; Hélio S Dutra; Radovan Borojevic; Martin Bonamino; Claudia Mermelstein; Maria Isabel D Rossi
Journal:  Stem Cells Int       Date:  2016-12-08       Impact factor: 5.443

5.  Isoproterenol induces an increase in muscle fiber size by the proliferation of Pax7-positive cells and in a mTOR-independent mechanism.

Authors:  Úrsula Maria C Bastos; Ivone de Andrade Rosa; John D Teixeira; Graciele Gonçalves; Manoel L Costa; Luis Eduardo M Quintas; Claudia Mermelstein
Journal:  Cell Biol Int       Date:  2019-06-05       Impact factor: 3.612

6.  Simvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage.

Authors:  Laise M Campos; Livia Guapyassu; Cyro Gomes; Victor Midlej; Marlene Benchimol; Claudia Mermelstein; Manoel Luis Costa
Journal:  Front Cell Dev Biol       Date:  2022-03-14

Review 7.  The Role of Embryonic Chick Muscle Cell Culture in the Study of Skeletal Myogenesis.

Authors:  Manoel L Costa; Arnon D Jurberg; Claudia Mermelstein
Journal:  Front Physiol       Date:  2021-05-20       Impact factor: 4.566
  7 in total

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