BACKGROUND:Coronary artery bypass grafting (CABG) with cardioplegic cardiac arrest and cardiopulmonary bypass (CPB) is associated with myocardial injury. The aim of this study was to investigate whether high-dose insulin therapy has a myocardial protective effect by enhancing early metabolic recovery of the arrested heart during revascularization. METHODS: A total of 44 patients undergoing elective CABG were randomized to receive intraoperative titrated intravenous insulin infusion (n = 22) or a fixed high-dose systemic insulin infusion at 5 mU/kg/min (n = 22). Blood samples were collected simultaneously from the radial artery and the coronary sinus before starting CPB and at 5 and 10 minutes after the release of the aortic cross-clamp to determine lactate, oxygen saturation, and hemoglobin concentration. Lactate extraction/excretion and myocardial oxygen extraction were calculated and compared between the two groups. The change in cardiac indices was determined immediately postoperatively as a measure of functional recovery, and the troponin I level was measured 4 hours postoperatively as an indicator of myocardial protection. RESULTS:Operative characteristics, including CPB and aortic cross-clamp time, were similar between the two groups. Arterial oxygen content was similar in both groups. The high-dose insulin therapy group had early extraction of lactate and higher oxygen extraction immediately postoperatively compared with the standard group. In addition, the high-dose insulin group had a lower troponin I level 4 hours postoperatively, with greater improvement in cardiac indices. CONCLUSIONS:High-dose insulin therapy promotes early metabolic recovery of the heart during elective CABG, leading to better myocardial protection and functional recovery.
RCT Entities:
BACKGROUND: Coronary artery bypass grafting (CABG) with cardioplegic cardiac arrest and cardiopulmonary bypass (CPB) is associated with myocardial injury. The aim of this study was to investigate whether high-dose insulin therapy has a myocardial protective effect by enhancing early metabolic recovery of the arrested heart during revascularization. METHODS: A total of 44 patients undergoing elective CABG were randomized to receive intraoperative titrated intravenous insulin infusion (n = 22) or a fixed high-dose systemic insulin infusion at 5 mU/kg/min (n = 22). Blood samples were collected simultaneously from the radial artery and the coronary sinus before starting CPB and at 5 and 10 minutes after the release of the aortic cross-clamp to determine lactate, oxygen saturation, and hemoglobin concentration. Lactate extraction/excretion and myocardial oxygen extraction were calculated and compared between the two groups. The change in cardiac indices was determined immediately postoperatively as a measure of functional recovery, and the troponin I level was measured 4 hours postoperatively as an indicator of myocardial protection. RESULTS: Operative characteristics, including CPB and aortic cross-clamp time, were similar between the two groups. Arterial oxygen content was similar in both groups. The high-dose insulin therapy group had early extraction of lactate and higher oxygen extraction immediately postoperatively compared with the standard group. In addition, the high-dose insulin group had a lower troponin I level 4 hours postoperatively, with greater improvement in cardiac indices. CONCLUSIONS: High-dose insulin therapy promotes early metabolic recovery of the heart during elective CABG, leading to better myocardial protection and functional recovery.
Authors: Andra E Duncan; Daniel I Sessler; Hiroaki Sato; Tamaki Sato; Keisuke Nakazawa; George Carvalho; Roupen Hatzakorzian; Takumi Codere-Maruyama; Alaa Abd-Elsayed; Somnath Bose; Tamer Said; Maria Mendoza-Cuartas; Hyndhavi Chowdary; Edward J Mascha; Dongsheng Yang; A Marc Gillinov; Thomas Schricker Journal: Anesthesiology Date: 2018-06 Impact factor: 7.892
Authors: Andra E Duncan; Babak Kateby Kashy; Sheryar Sarwar; Akhil Singh; Olga Stenina-Adognravi; Steffen Christoffersen; Andrej Alfirevic; Shiva Sale; Dongsheng Yang; James D Thomas; Marc Gillinov; Daniel I Sessler Journal: Anesthesiology Date: 2015-08 Impact factor: 7.892