Literature DB >> 18036817

Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4'-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology.

Rosaleen J Anderson1, Paul W Groundwater, Yongxue Huang, Arthur L James, Sylvain Orenga, Annette Rigby, Céline Roger-Dalbert, John D Perry.   

Abstract

The synthesis and initial evaluation of novel chromogenic substrates with potential in the detection and differentiation of cultured bacterial colonies are described. The substrates were readily hydrolysed by specific aminopeptidase activity to release the chromogen, 9-(4'-aminophenyl)-10-methylacridinium salt, which provided a clear visual indication of the presence of the corresponding bacteria.

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Year:  2007        PMID： 18036817     DOI： 10.1016/j.bmcl.2007.11.018

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Detection of β-alanyl aminopeptidase as a biomarker for Pseudomonas aeruginosa in the sputum of patients with cystic fibrosis using exogenous volatile organic compound evolution.

Authors:  Ryan Thompson; Dominic Stephenson; Hannah E Sykes; John D Perry; Stephen P Stanforth; John R Dean
Journal:  RSC Adv       Date:  2020-03-12       Impact factor: 4.036

2.  The Synthesis of L-Alanyl and β-Alanyl Derivatives of 2-Aminoacridone and Their Application in the Detection of Clinically-Important Microorganisms.

Authors:  Marie Cellier; Arthur L James; Sylvain Orenga; John D Perry; Graeme Turnbull; Stephen P Stanforth
Journal:  PLoS One       Date:  2016-07-08       Impact factor: 3.240
  2 in total

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