| Literature DB >> 18036151 |
N G Hatcher1, X Zhang, J N Stuart, L L Moroz, J V Sweedler, R Gillette.
Abstract
Serotonin (5-HT) is an intrinsic modulator of neural network excitation states in gastropod molluscs. 5-HT and related indole metabolites were measured in single, well-characterized serotonergic neurons of the feeding motor network of the predatory sea-slug Pleurobranchaea californica. Indole amounts were compared between paired hungry and satiated animals. Levels of 5-HT and its metabolite 5-HT-SO4 in the metacerebral giant neurons were observed in amounts approximately four-fold and two-fold, respectively, below unfed partners 24 h after a satiating meal. Intracellular levels of 5-hydroxyindole acetic acid and of free tryptophan did not differ significantly with hunger state. These data demonstrate that neurotransmitter levels and their metabolites can vary in goal-directed neural networks in a manner that follows internal state.Entities:
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Year: 2007 PMID： 18036151 PMCID： PMC4024471 DOI： 10.1111/j.1471-4159.2007.05084.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372