| Literature DB >> 18035806 |
Srunthron Sunanchaikarn1, Apiradee Theamboonlers, Voranush Chongsrisawat, Pornsak Yoocharoen, Piyanit Tharmaphornpilas, Porpit Warinsathien, Supakarn Sinlaparatsamee, Siriraj Paupunwatana, Kasemporn Chaiear, Sawan Khwanjaipanich, Yong Poovorawan.
Abstract
HCV can be classified into 6 major genotypes based on the phylogenetic analysis of the genomic sequences. The 3 major genotypes found in Thailand are 3, 1 and 6, respectively. In 2004, an epidemiological survey was carried out to evaluate the seroprevalence of HCV infections among populations aged 2-60 years in four provinces of Thailand, representing the North, Northeast, Center and South of the country, respectively. One hundred and twenty five out of 5,825 serum samples (2.15%) were positive for anti-HCV by ELISA. Fifty eight out of 100 anti-HCV positive samples (58.0%) were positive by RT-PCR of the 5'UTR. The core region of 45 representative samples was sequenced allowing classification into genotype variants 1a (6.7%), 1b (26.7%), 2a (2.2%), 2c (2.2%), 3a (51.1%), 3b (2.2%) and 6 (8.9%). This information might be crucial for public health surveillance and prevention of HCV infection.Entities:
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Year: 2007 PMID： 18035806
Source DB: PubMed Journal: Asian Pac J Allergy Immunol ISSN： 0125-877X Impact factor: 2.310