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Literature DB >> 18035409

PKC signaling in oxidative hepatic damage.

Mariapaola Nitti¹, Maria A Pronzato, Umberto M Marinari, Cinzia Domenicotti.

Abstract

Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as "stress sensors". Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial role of PKC as a redox sensitive signaling molecule has been widely accepted.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2007 PMID： 18035409 DOI： 10.1016/j.mam.2007.09.001

Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997

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Cited

14 in total

Review 1. Rationally designed peptide regulators of protein kinase C.

Authors: Eric N Churchill; Nir Qvit; Daria Mochly-Rosen
Journal: Trends Endocrinol Metab Date: 2008-12-04 Impact factor: 12.015

2. CD73-Adenosine A₁R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP₃-Ca²⁺/DAG-PKC Signaling Pathway.

Authors: Zhenni Liu; Xue Wu; Qi Wang; Zixuan Li; Xueqi Liu; Xiaodong Sheng; Hong Zhu; Mengda Zhang; Junrui Xu; Xiaowen Feng; Baoming Wu; Xiongwen Lv
Journal: Front Pharmacol Date: 2022-06-16 Impact factor: 5.988

3. Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis.

Authors: Mustapha Najimi; Xavier Stéphenne; Christine Sempoux; Etienne Sokal
Journal: World J Gastroenterol Date: 2014-02-14 Impact factor: 5.742

4. Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms.

Authors: L Massip; C Garand; A Labbé; E Perreault; R V N Turaga; V A Bohr; M Lebel
Journal: Oncogene Date: 2009-12-07 Impact factor: 9.867

5. Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression.

Authors: Sai-Bin Wang; Qian Ye; Jun-Wei Tu; Xian-Yan Yu
Journal: Int J Clin Exp Pathol Date: 2018-07-01

6. Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.

Authors: Mengyao Jin; Anil Kumar; Santosh Kumar
Journal: PLoS One Date: 2012-04-18 Impact factor: 3.240

PKC signaling in oxidative hepatic damage.

Review 1. Rationally designed peptide regulators of protein kinase C.

2. CD73-Adenosine A₁R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP₃-Ca²⁺/DAG-PKC Signaling Pathway.

3. Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis.

4. Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms.

5. Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression.

6. Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.

7. Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress.

8. Roles of Oxidized Diacylglycerol for Carbon Tetrachloride-induced Liver Injury and Fibrosis in Mouse.

9. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.

10. Hepatoprotective and antioxidant activity of N-acetyl cysteine in carbamazepine-administered rats.