Literature DB >> 18034647

Polycation-based nanoparticle delivery for improved RNA interference therapeutics.

Kenneth A Howard1, Jørgen Kjems.   

Abstract

Small-interfering RNA (siRNA)-mediated silencing of genes implicated in disease by the process of RNA interference offers a novel genetic medicine approach. Polymeric nanoparticles (or polyplexes) formed by self-assembly of polycations with siRNA can be used for site-specific delivery, cellular uptake and intracellular trafficking as a strategy to improve the therapeutic potential of siRNA. This review describes the application of polyplexes for in vivo delivery of synthetic siRNA with focus given to systemic and mucosal routes and in vivo requirements. Issues including use of stimuli-responsive systems for intracellular trafficking of siRNA are discussed as part of necessary future directives towards the development of RNA-based clinical therapeutics.

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Year:  2007        PMID： 18034647     DOI： 10.1517/14712598.7.12.1811

Source DB:  PubMed          Journal:  Expert Opin Biol Ther        ISSN： 1471-2598            Impact factor:   4.388


  15 in total

Review 1.  Methods for the preparation and manufacture of polymeric nanoparticles.

Authors:  Christine Vauthier; Kawthar Bouchemal
Journal:  Pharm Res       Date:  2008-12-24       Impact factor: 4.200

2.  The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

Authors:  Shan Gao; Frederik Dagnaes-Hansen; Ebbe Juel Bech Nielsen; Jesper Wengel; Flemming Besenbacher; Kenneth Alan Howard; Jørgen Kjems
Journal:  Mol Ther       Date:  2009-04-28       Impact factor: 11.454

3.  The application of RNAi-based treatments for inflammatory bowel disease.

Authors:  Morten Tobias Jarlstad Olesen; Borja Ballarín-González; Kenneth Alan Howard
Journal:  Drug Deliv Transl Res       Date:  2014-02       Impact factor: 4.617

4.  Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.

Authors:  Ebbe J B Nielsen; Jan M Nielsen; Daniel Becker; Alexander Karlas; Hridayesh Prakash; Sys Z Glud; Jonathan Merrison; Flemming Besenbacher; Thomas F Meyer; Jørgen Kjems; Kenneth A Howard
Journal:  Pharm Res       Date:  2010-09-08       Impact factor: 4.200

5.  Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo.

Authors:  Patric Lundberg; Hui-Jung Yang; Seung-Jae Jung; Mark A Behlke; Scott D Rose; Edouard M Cantin
Journal:  J Control Release       Date:  2011-11-07       Impact factor: 9.776

6.  Very long chain N4, N9 -diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA and siRNA delivery.

Authors:  Hassan M Ghonaim; Shi Li; Ian S Blagbrough
Journal:  Pharm Res       Date:  2008-09-10       Impact factor: 4.200

7.  N1,N12-Diacyl spermines: SAR studies on non-viral lipopolyamine vectors for plasmid DNA and siRNA formulation.

Authors:  Hassan M Ghonaim; Shi Li; Ian S Blagbrough
Journal:  Pharm Res       Date:  2009-10-30       Impact factor: 4.200

8.  Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

Authors:  Yoram Rudy; Michael J Ackerman; Donald M Bers; Colleen E Clancy; Steven R Houser; Barry London; Andrew D McCulloch; Dennis A Przywara; Randall L Rasmusson; R John Solaro; Natalia A Trayanova; David R Van Wagoner; András Varró; James N Weiss; David A Lathrop
Journal:  Circulation       Date:  2008-09-09       Impact factor: 29.690

9.  Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target.

Authors:  Lijun Jia; Jie Yang; Xinbao Hao; Min Zheng; Hongbin He; Xiufang Xiong; Liang Xu; Yi Sun
Journal:  Clin Cancer Res       Date:  2010-01-26       Impact factor: 12.531

10.  Oligonucleotide delivery to the lung: waiting to inhale.

Authors:  Jørgen Kjems; Kenneth A Howard
Journal:  Mol Ther Nucleic Acids       Date:  2012-01-24       Impact factor: 10.183
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