Use of evidence in economic decision models: practical issues and methodological challenges.

This paper outlines the current 'state of play' regarding the use of evidence in decision modelling and highlights both practical issues and methodological challenges related to identifying, combining and reporting evidence to inform decision model parameters and structure. Based on discussions at two MRC HSRC-funded workshops consisting of 37 experts from a range of disciplines (i.e. decision-makers, health economists, information specialists, operations researchers and statisticians), it aims to derive a multi-disciplinary standpoint on the appropriate use of evidence in economic decision models and, where applicable, offer some suggestions for good modelling practice. Gaps in the established methodology knowledge base are identified for future research. Copyright (c) 2007 John Wiley & Sons, Ltd.