OBJECTIVE: The effects of different therapies on enthesitis/osteitis in active ankylosing spondylitis (AS) were evaluated by magnetic resonance imaging (MRI). The aim was to assess the role of quantitative MRI in the evaluation of AS treatment efficacy. MATERIALS AND METHODS: Thirty patients with active spondylitis or bilateral sacroiliitis were selected and followed up for 1 year. Ten of the patients were treated only with non-steroidal anti-inflammatory drugs, 10 patients additionally received at baseline an intravenous pulse of glucocorticoids and 10 patients were treated with regular infusions of infliximab. Disease activity was measured according to clinical instruments and laboratory tests. For each patient, one selected inflamed lesion was followed from baseline through control visits quantitatively by diffusion-weighted imaging (DWI) measuring the apparent diffusion coefficient (ADC) and by dynamic contrast-enhanced imaging (DCEI) with evaluation of the enhancement factor (f(enh)) and enhancement gradient (g(enh)). RESULTS: Clinical and quantitative MRI parameters diminished significantly with regression of the inflammatory activity. The improvement in AS was most pronounced in patients treated with infliximab; after 12 months the ADC diminished from an average of 1.31 to 0.88 x 10(-3) mm(2)/s, f(enh) from 1.85 to 0.60, and g(enh) from 3.09 to 1.40 %/s. CONCLUSION: Diffusion-weighted imaging and DCEI were shown to be effective in quantifying changes in inflammation in skeletal lesions during the treatment of AS, and could therefore be convenient for assessing treatment efficacy. To the best of our knowledge this is the first time DWI was used to evaluate the activity of skeletal inflammation in rheumatic diseases such as AS.
OBJECTIVE: The effects of different therapies on enthesitis/osteitis in active ankylosing spondylitis (AS) were evaluated by magnetic resonance imaging (MRI). The aim was to assess the role of quantitative MRI in the evaluation of AS treatment efficacy. MATERIALS AND METHODS: Thirty patients with active spondylitis or bilateral sacroiliitis were selected and followed up for 1 year. Ten of the patients were treated only with non-steroidal anti-inflammatory drugs, 10 patients additionally received at baseline an intravenous pulse of glucocorticoids and 10 patients were treated with regular infusions of infliximab. Disease activity was measured according to clinical instruments and laboratory tests. For each patient, one selected inflamed lesion was followed from baseline through control visits quantitatively by diffusion-weighted imaging (DWI) measuring the apparent diffusion coefficient (ADC) and by dynamic contrast-enhanced imaging (DCEI) with evaluation of the enhancement factor (f(enh)) and enhancement gradient (g(enh)). RESULTS: Clinical and quantitative MRI parameters diminished significantly with regression of the inflammatory activity. The improvement in AS was most pronounced in patients treated with infliximab; after 12 months the ADC diminished from an average of 1.31 to 0.88 x 10(-3) mm(2)/s, f(enh) from 1.85 to 0.60, and g(enh) from 3.09 to 1.40 %/s. CONCLUSION: Diffusion-weighted imaging and DCEI were shown to be effective in quantifying changes in inflammation in skeletal lesions during the treatment of AS, and could therefore be convenient for assessing treatment efficacy. To the best of our knowledge this is the first time DWI was used to evaluate the activity of skeletal inflammation in rheumatic diseases such as AS.
Authors: J Braun; X Baraliakos; W Golder; K-G Hermann; J Listing; J Brandt; M Rudwaleit; S Zuehlsdorf; M Bollow; J Sieper; D van der Heijde Journal: Ann Rheum Dis Date: 2004-04-05 Impact factor: 19.103
Authors: M Cova; Y S Kang; H Tsukamoto; L C Jones; E McVeigh; B L Neff; C J Herold; W W Scott; D S Hungerford; E A Zerhouni Journal: Radiology Date: 1991-05 Impact factor: 11.105
Authors: T M Moehler; H Hawighorst; K Neben; G Egerer; J Hillengass; R Max; A Benner; A D Ho; G van Kaick; H Goldschmidt Journal: Int J Cancer Date: 2001-09 Impact factor: 7.396
Authors: Filip De Keyser; Dominique Baeten; Filip Van den Bosch; Elli Kruithof; Gust Verbruggen; Herman Mielants; Eric Veys Journal: Drugs Date: 2004 Impact factor: 9.546
Authors: Olaf Dietrich; José G Raya; Julia Sommer; Michael Deimling; Maximilian F Reiser; Andrea Baur-Melnyk Journal: Eur Radiol Date: 2004-12-31 Impact factor: 5.315
Authors: Nicholas Bhojwani; Peter Szpakowski; Sasan Partovi; Martin H Maurer; Ulrich Grosse; Hendrik von Tengg-Kobligk; Lisa Zipp-Partovi; Nathan Fergus; Christos Kosmas; Konstantin Nikolaou; Mark R Robbin Journal: Quant Imaging Med Surg Date: 2015-10
Authors: Mitja Rupreht; Vladimir Jevtič; Igor Serša; Matjaž Vogrin; Tomaž Seruga; Marko Jevšek Journal: Skeletal Radiol Date: 2011-08-31 Impact factor: 2.199