INTRODUCTION: Non small cell lung carcinomas (NSCLC) are known to secrete various cytokines such as VEGF (vascular endothelial growth factor), G-CSF (granulocyte-colony stimulating factor) and TGF-beta (transforming growth factor-beta) that may stimulate bone marrow activity. PURPOSE: This study reports on the relationship between serum levels of VEGF, G-CSF, TGF-beta and FDG uptake by the bone marrow in NSCLC patients. METHODS: Thirty-three patients suffering from newly diagnosed NSCLC who were successively referred to undergo an FDG PET scan as a part of their routine staging procedure and that did not suffer from bone metastases were included in the study. FDG bone marrow activity was determined in all patients and related to pre-treatment VEGF, G-CSF and TGF-beta serum levels. RESULTS: Mean standardized uptake values (SUV mean) of the bone marrow ranged from 0.1 to 2.1 (mean 1.1). G-CSF, VEGF and TGF-beta serum levels ranged from 13.5 to 110 pg/ml (mean 41.4 pg/ml), from 95 to 3,221 pg/ml (mean 1,111 pg/ml) and from 269 to 615 pg/ml (mean 387 pg/ml), respectively. SUV mean values of the bone marrow significantly correlated with TGF-beta serum measurements (r = 0.621, p < 0.0001), but not with VEGF and G-CSF measurements. CONCLUSION: FDG uptake by bone marrow in newly diagnosed NSCLC patients correlates with serum levels of TGF-beta, but not with VEGF or G-CSF levels.
INTRODUCTION:Non small cell lung carcinomas (NSCLC) are known to secrete various cytokines such as VEGF (vascular endothelial growth factor), G-CSF (granulocyte-colony stimulating factor) and TGF-beta (transforming growth factor-beta) that may stimulate bone marrow activity. PURPOSE: This study reports on the relationship between serum levels of VEGF, G-CSF, TGF-beta and FDG uptake by the bone marrow in NSCLCpatients. METHODS: Thirty-three patients suffering from newly diagnosed NSCLC who were successively referred to undergo an FDG PET scan as a part of their routine staging procedure and that did not suffer from bone metastases were included in the study. FDG bone marrow activity was determined in all patients and related to pre-treatment VEGF, G-CSF and TGF-beta serum levels. RESULTS: Mean standardized uptake values (SUV mean) of the bone marrow ranged from 0.1 to 2.1 (mean 1.1). G-CSF, VEGF and TGF-beta serum levels ranged from 13.5 to 110 pg/ml (mean 41.4 pg/ml), from 95 to 3,221 pg/ml (mean 1,111 pg/ml) and from 269 to 615 pg/ml (mean 387 pg/ml), respectively. SUV mean values of the bone marrow significantly correlated with TGF-beta serum measurements (r = 0.621, p < 0.0001), but not with VEGF and G-CSF measurements. CONCLUSION: FDG uptake by bone marrow in newly diagnosed NSCLCpatients correlates with serum levels of TGF-beta, but not with VEGF or G-CSF levels.
Authors: A Colasante; N Mascetra; M Brunetti; G Lattanzio; M Diodoro; S Caltagirone; P Musiani; F B Aiello Journal: Am J Respir Crit Care Med Date: 1997-09 Impact factor: 21.405
Authors: M Souvatzoglou; S I Ziegler; M J Martinez; R Busch; G Dzewas; M Schwaiger; F Bengel Journal: Eur J Nucl Med Mol Imaging Date: 2006-09-05 Impact factor: 9.236
Authors: Victoria C Liu; Larry Y Wong; Thomas Jang; Ali H Shah; Irwin Park; Ximing Yang; Qiang Zhang; Scott Lonning; Beverly A Teicher; Chung Lee Journal: J Immunol Date: 2007-03-01 Impact factor: 5.422
Authors: Linhua Zou; Brian Barnett; Hana Safah; Vincent F Larussa; Melina Evdemon-Hogan; Peter Mottram; Shuang Wei; Odile David; Tyler J Curiel; Weiping Zou Journal: Cancer Res Date: 2004-11-15 Impact factor: 12.701
Authors: Jeong Won Lee; Sung Yong Kim; Sun Wook Han; Jong Eun Lee; Hyun Ju Lee; Nam Hun Heo; Sang Mi Lee Journal: EJNMMI Res Date: 2020-06-30 Impact factor: 3.138
Authors: Sarah A Mattonen; Guido A Davidzon; Jalen Benson; Ann N C Leung; Minal Vasanawala; George Horng; Joseph B Shrager; Sandy Napel; Viswam S Nair Journal: Radiology Date: 2019-09-17 Impact factor: 29.146