BACKGROUND: We have recently shown that ischemic stroke causes a stress-mediator-induced long-lasting immunodepressive state in mice. METHODS: Using head magnetic resonance imaging and standardized immunoassays, we prospectively investigated whether poststroke immunodepression is also seen in humans. RESULTS: Compared to healthy volunteers (n = 30), a rapid depression of lymphocyte counts and a functional deactivation of monocytes and T helper type 1 cells was observed in acute stroke patients (SP; n = 40). Immunodepression was more pronounced in patients with severe clinical deficit or large infarction. On admission the combination of monocytic tumor necrosis factor alpha release ex vivo and the National Institute of Health Stroke Scale score were the best predictors for nosocomial infection, preferentially affecting older SP. CONCLUSION: Our data provide evidence for an immediate suppression of cell-mediated immune responses after ischemic stroke in humans. (c) 2007 S. Karger AG, Basel.
BACKGROUND: We have recently shown that ischemic stroke causes a stress-mediator-induced long-lasting immunodepressive state in mice. METHODS: Using head magnetic resonance imaging and standardized immunoassays, we prospectively investigated whether poststroke immunodepression is also seen in humans. RESULTS: Compared to healthy volunteers (n = 30), a rapid depression of lymphocyte counts and a functional deactivation of monocytes and T helper type 1 cells was observed in acute strokepatients (SP; n = 40). Immunodepression was more pronounced in patients with severe clinical deficit or large infarction. On admission the combination of monocytic tumor necrosis factor alpha release ex vivo and the National Institute of Health Stroke Scale score were the best predictors for nosocomial infection, preferentially affecting older SP. CONCLUSION: Our data provide evidence for an immediate suppression of cell-mediated immune responses after ischemic stroke in humans. (c) 2007 S. Karger AG, Basel.
Authors: Ángel Chamorro; Andreas Meisel; Anna M Planas; Xabier Urra; Diederik van de Beek; Roland Veltkamp Journal: Nat Rev Neurol Date: 2012-06-05 Impact factor: 42.937
Authors: Andreas Hug; Bettina Mürle; Alexander Dalpke; Markus Zorn; Arthur Liesz; Roland Veltkamp Journal: Neurocrit Care Date: 2011-06 Impact factor: 3.210
Authors: Antje Vogelgesang; Verena E L May; Uwe Grunwald; Maren Bakkeboe; Soenke Langner; Henry Wallaschofski; Christof Kessler; Barbara M Bröker; Alexander Dressel Journal: PLoS One Date: 2010-01-14 Impact factor: 3.240